Anticancer Effects of Salvia miltiorrhiza Alcohol Extract on Oral Squamous Carcinoma Cells
Joint Authors
Kuo, Yu-Hsuan
Chu, Ling-Ya
Lee, Chia-Ying
Chen, Zong-Shiow
Tsai, Wan-Chi
Wang, Wen-Hung
Tyan, Yu Chang
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-29
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Researchers have reported significant effects from Danshen (Salvia miltiorrhiza) in terms of inhibiting tumor cell proliferation and promoting apoptosis in breast cancer, hepatocellular carcinomas, promyelocytic leukemia, and clear cell ovary carcinomas.
Here we report our data indicating that Danshen extracts, especially alcohol extract, significantly inhibited the proliferation of the human oral squamous carcinoma (OSCC) cell lines HSC-3 and OC-2.
We also observed that Danshen alcohol extract activated the caspase-3 apoptosis executor by impeding members of the inhibitor of apoptosis (IAP) family, but not by regulating the Bcl-2-triggered mitochondrial pathway in OSCC cells.
Our data also indicate that the extract exerted promising effects in vivo, with HSC-3 tumor xenograft growth being suppressed by 40% and 69% following treatment with Danshen alcohol extract at 50 and 100 mg/kg, respectively, for 34 days.
Combined, our results indicate appreciable anticancer activity and significant potential for Danshen alcohol extract as a natural antioxidant and herbal human oral cancer chemopreventive drug.
American Psychological Association (APA)
Wang, Wen-Hung& Kuo, Yu-Hsuan& Chu, Ling-Ya& Lee, Chia-Ying& Tyan, Yu Chang& Chen, Zong-Shiow…[et al.]. 2017. Anticancer Effects of Salvia miltiorrhiza Alcohol Extract on Oral Squamous Carcinoma Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1154048
Modern Language Association (MLA)
Wang, Wen-Hung…[et al.]. Anticancer Effects of Salvia miltiorrhiza Alcohol Extract on Oral Squamous Carcinoma Cells. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1154048
American Medical Association (AMA)
Wang, Wen-Hung& Kuo, Yu-Hsuan& Chu, Ling-Ya& Lee, Chia-Ying& Tyan, Yu Chang& Chen, Zong-Shiow…[et al.]. Anticancer Effects of Salvia miltiorrhiza Alcohol Extract on Oral Squamous Carcinoma Cells. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1154048
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154048