Antioxidant Properties and Cardioprotective Mechanism of Malaysian Propolis in Rats
Joint Authors
Sulaiman, Siti Amrah
Afroz, Rizwana
Tanvir, E. M.
Khalil, Md. Ibrahim
Ahmmed, Istiyak
Ahmed, Romana
Rumpa, Nur-E-Noushin
Hossen, Md. Sakib
Paul, Sudip
Gan, Siew Hua
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-02
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Propolis contains high concentrations of polyphenols, flavonoids, tannins, ascorbic acid, and reducing sugars and proteins.
Malaysian Propolis (MP) has been reported to exhibit high 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical-scavenging activity and ferric reducing antioxidant power (FRAP) values.
Herein, we report the antioxidant properties and cardioprotective properties of MP in isoproterenol- (ISO-) induced myocardial infarction in rats.
Male Wistar rats (n=32) were pretreated orally with an ethanol extract of MP (100 mg/kg/day) for 30 consecutive days.
Subcutaneous injection of ISO (85 mg/kg in saline) for two consecutive days caused a significant increase in serum cardiac marker enzymes and cardiac troponin I levels and altered serum lipid profiles.
In addition significantly increased lipid peroxides and decreased activities of cellular antioxidant defense enzymes were observed in the myocardium.
However, pretreatment of ischemic rats with MP ameliorated the biochemical parameters, indicating the protective effect of MP against ISO-induced ischemia in rats.
Histopathological findings obtained for the myocardium further confirmed the biochemical findings.
It is concluded that MP exhibits cardioprotective activity against ISO-induced oxidative stress through its direct cytotoxic radical-scavenging activities.
It is also plausible that MP contributed to endogenous antioxidant enzyme activity via inhibition of lipid peroxidation.
American Psychological Association (APA)
Ahmed, Romana& Tanvir, E. M.& Hossen, Md. Sakib& Afroz, Rizwana& Ahmmed, Istiyak& Rumpa, Nur-E-Noushin…[et al.]. 2017. Antioxidant Properties and Cardioprotective Mechanism of Malaysian Propolis in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1154051
Modern Language Association (MLA)
Ahmed, Romana…[et al.]. Antioxidant Properties and Cardioprotective Mechanism of Malaysian Propolis in Rats. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1154051
American Medical Association (AMA)
Ahmed, Romana& Tanvir, E. M.& Hossen, Md. Sakib& Afroz, Rizwana& Ahmmed, Istiyak& Rumpa, Nur-E-Noushin…[et al.]. Antioxidant Properties and Cardioprotective Mechanism of Malaysian Propolis in Rats. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1154051
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154051