![](/images/graphics-bg.png)
The Antidiabetic Activity of Nigella sativa and Propolis on Streptozotocin-Induced Diabetes and Diabetic Nephropathy in Male Rats
Joint Authors
El Rabey, Haddad A.
Al-Seeni, Madeha N.
Bakhashwain, Amal S.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-16
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
This study was conducted to compare the ameliorative effect of Nigella sativa and propolis methanol extract on streptozotocin-induced diabetic male rats and treating diabetic nephropathy.
Forty male Albino rats were divided into four groups; the first group was the negative control fed standard diet.
The other 30 rats were injected with streptozotocin to induce diabetes by a single intravenous injection and then divided equally into three groups; the second group was the positive diabetic control; the third and the fourth groups were treated orally with 20% w/w Nigella sativa seeds methanol extract and propolis methanol extract (20% w/w), respectively.
The rats of the second group showed increased glucose levels and lipid peroxide accompanied with reduction in superoxide dismutase, catalase, and glutathione-S-transferase enzyme activities compared with the negative control.
Carboxymethyl lysine, interleukin-6, and immunoglobulins were also increased as a result of diabetes.
Kidney function parameters were also elevated, while potassium and sodium levels were decreased.
Moreover, tissues of kidney and pancreas showed severe histopathological changes.
Treating the diabetic rats with Nigella sativa and propolis methanol extract in the third and fourth groups, respectively, ameliorated all altered biochemical and pathological examinations approaching the negative control.
Propolis was more effective than Nigella sativa.
American Psychological Association (APA)
El Rabey, Haddad A.& Al-Seeni, Madeha N.& Bakhashwain, Amal S.. 2017. The Antidiabetic Activity of Nigella sativa and Propolis on Streptozotocin-Induced Diabetes and Diabetic Nephropathy in Male Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1154071
Modern Language Association (MLA)
Bakhashwain, Amal S.…[et al.]. The Antidiabetic Activity of Nigella sativa and Propolis on Streptozotocin-Induced Diabetes and Diabetic Nephropathy in Male Rats. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-14.
https://search.emarefa.net/detail/BIM-1154071
American Medical Association (AMA)
El Rabey, Haddad A.& Al-Seeni, Madeha N.& Bakhashwain, Amal S.. The Antidiabetic Activity of Nigella sativa and Propolis on Streptozotocin-Induced Diabetes and Diabetic Nephropathy in Male Rats. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1154071
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154071