Clinicopathological and Prognostic Roles of STAT3 and Its Phosphorylation in Glioma
Joint Authors
Liang, Bo
Gu, Ning
Li, Shuang-Yang
Gong, Hui-Zhi
Wang, Ling-Xue
Zhao, Yu-Xiu
Lu, Jia
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-23
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Glioma is defined as a common brain tumor which causes severe disability or death.
As many genes are reported to relate with glioma’s occurrence and development, their prognostic and therapeutic value still remains uncertain.
This study aimed at investigating the association between STAT3/p-STAT3 and glioma prognosis.
Nine studies (12 trials) scored ≥5 on the Newcastle-Ottawa scale were meta-analysed from the Medline, Embase, and Web of Science databases.
We found that STAT3/p-STAT3 overexpression in glioma patients was associated with worse overall survival (hazard ratio HR=1.40, 95%confidence interval CI=1.05~1.86, P=0.020), progression-free survival (HR=2.05, 95%CI=1.63~2.58, P<0.001), and better recurrence-free survival (HR=0.37, 95%CI=0.15~0.95, P<0.039).
Subgroup analysis implied that STAT3/p-STAT3 overexpression was associated with worse OS in standard treatment (HR=1.80, 95%CI=1.06~3.04, P=0.030), and in China (HR=2.18, 95%CI=1.77~2.70, P<0.001), and metaregression analysis indicated countries (P=0.001) may be the source of heterogeneity in our study.
In conclusion, we suggested STAT3/p-STAT3 was associated with poor prognosis in patients with glioma, which indicated that STAT3/p-STAT3 might be a valuable prognostic biomarker and a promising therapeutic target for glioma.
American Psychological Association (APA)
Liang, Bo& Li, Shuang-Yang& Gong, Hui-Zhi& Wang, Ling-Xue& Lu, Jia& Zhao, Yu-Xiu…[et al.]. 2020. Clinicopathological and Prognostic Roles of STAT3 and Its Phosphorylation in Glioma. Disease Markers،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1154090
Modern Language Association (MLA)
Liang, Bo…[et al.]. Clinicopathological and Prognostic Roles of STAT3 and Its Phosphorylation in Glioma. Disease Markers No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1154090
American Medical Association (AMA)
Liang, Bo& Li, Shuang-Yang& Gong, Hui-Zhi& Wang, Ling-Xue& Lu, Jia& Zhao, Yu-Xiu…[et al.]. Clinicopathological and Prognostic Roles of STAT3 and Its Phosphorylation in Glioma. Disease Markers. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1154090
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154090