miR-106a-5p Functions as a Tumor Suppressor by Targeting VEGFA in Renal Cell Carcinoma

Abstract EN

MicroRNAs (miRNAs) regulate progression of different cancers.

Nevertheless, there is limited information regarding the role of miR-106a-5p in renal cell carcinoma (RCC).

Herein, we demonstrate that miR-106a-5p levels are drastically decreased in clear cell RCC (ccRCC) tissues and cell lines, which subsequently contribute to a poor patient overall survival and a high tumor stage.

By screening and analyzing, we found that miR-106a-5p directly targets the 3′-UTR of the VEGFA mRNA and led to a decrease in VEGFA.

This process is important for tumor cells’ growth and colony formation, and overexpression of miR-106a-5p can especially kill kidney tumor cells.

Therefore, our data reveal that miR-106a-5p functions as a tumor suppressor by regulating VEGFA and ccRCC may be susceptible to miR-106a-5p therapy.