Targeted Metabolomics for Plasma Amino Acids and Carnitines in Patients with Metabolic Syndrome Using HPLC-MSMS
Joint Authors
Yang, Song
Liu, He
Gong, Li-li
Han, Fei-fei
Xuan, Ling-ling
Lv, Ya-li
Liu, Li-hong
Zhang, Wen
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Metabolic syndrome (MetS) is a health disorder characterized by metabolic abnormalities that predict an increased risk to develop cardiovascular disease (CVD) and type 2 diabetes.
Biomarkers can provide an insight into the novel mechanism for MetS and can be potentially used for personalized response to therapies.
We exploited a targeted HPLC-MS/MS method to characterize plasma amino acids and carnitine metabolic profile in MetS patients.
A training set (40 cases and 40 controls) and validation set (80 MetS patients and 80 healthy controls) were carried out to find the metabolic profiles.
We discovered two carnitine metabolites including hydroxydecanoyl carnitine and methylglutarylcarnitine.
Our results indicated that the decreased level of hydroxydecanoyl carnitine and methylglutarylcarnitine may be associated with the risk of MetS.
These biomarkers may improve the risk prediction and provide a novel tool for monitoring of the progression of disease and response to treatment in MetS patients.
American Psychological Association (APA)
Gong, Li-li& Yang, Song& Zhang, Wen& Han, Fei-fei& Xuan, Ling-ling& Lv, Ya-li…[et al.]. 2020. Targeted Metabolomics for Plasma Amino Acids and Carnitines in Patients with Metabolic Syndrome Using HPLC-MSMS. Disease Markers،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1154107
Modern Language Association (MLA)
Gong, Li-li…[et al.]. Targeted Metabolomics for Plasma Amino Acids and Carnitines in Patients with Metabolic Syndrome Using HPLC-MSMS. Disease Markers No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1154107
American Medical Association (AMA)
Gong, Li-li& Yang, Song& Zhang, Wen& Han, Fei-fei& Xuan, Ling-ling& Lv, Ya-li…[et al.]. Targeted Metabolomics for Plasma Amino Acids and Carnitines in Patients with Metabolic Syndrome Using HPLC-MSMS. Disease Markers. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1154107
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154107