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Investigation of Lipid Profile and Clinical Manifestations in SCA Children
Joint Authors
Santiago, Rayra Pereira
Yahouédéhou, Sètondji Cocou Modeste Alexandre
Fonseca, Cleverson Alves
Figueiredo, Camylla Vilas Boas
Fiuza, Luciana Magalhães
Aleluia, Milena Magalhães
Carvalho, Suellen Pinheiro
da Guarda, Caroline Conceição
Fernandes, Camila Felix de Lima
Neres, Joelma Santana dos Santos
Oliveira, Antonio Mateus de Jesus
de Oliveira, Rodrigo Mota
Nascimento, Valma Maria Lopes
Rocha, Larissa Carneiro
Gonçalves, Marilda Souza
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-20
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Introduction.
Clinical complications in sickle cell anemia (SCA) are heterogeneous and involve several molecules.
It has been suggested that SCA individuals present a dyslipidemic phenotype and that lipid parameters are associated with severe clinical complications, such as pulmonary hypertension.
We sought to investigate associations between lipid parameters and clinical manifestations, as well as other laboratory parameters in a population of pediatric SCA patients.
Methods.
Our cross-sectional evaluation included 126 SCA patients in steady state and who were not undergoing lipid-lowering therapy.
Hematological and biochemical parameters were characterized, and previous clinical manifestations were investigated.
Results.
Total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels were increased in patients with a previous history of pneumonia, which also positively correlated with HbS levels.
Decreased LDL-C levels were also associated with leg ulcers and anemia.
Elevated high-density lipoprotein cholesterol (HDL-C) levels were associated with pain crises, increased viscosity, and decreased hemolysis.
Several studies have determined that lipids play a role in the vascular impairment seen in SCA, which was corroborated by our findings.
Conclusions.
In sum, our results suggest that total cholesterol, HDL-C, and LDL-C levels are associated with hemolysis and anemia markers and, most importantly, with clinical complications related to vasculopathy in SCA.
American Psychological Association (APA)
da Guarda, Caroline Conceição& Yahouédéhou, Sètondji Cocou Modeste Alexandre& Santiago, Rayra Pereira& Fernandes, Camila Felix de Lima& Neres, Joelma Santana dos Santos& Oliveira, Antonio Mateus de Jesus…[et al.]. 2020. Investigation of Lipid Profile and Clinical Manifestations in SCA Children. Disease Markers،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1154109
Modern Language Association (MLA)
da Guarda, Caroline Conceição…[et al.]. Investigation of Lipid Profile and Clinical Manifestations in SCA Children. Disease Markers No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1154109
American Medical Association (AMA)
da Guarda, Caroline Conceição& Yahouédéhou, Sètondji Cocou Modeste Alexandre& Santiago, Rayra Pereira& Fernandes, Camila Felix de Lima& Neres, Joelma Santana dos Santos& Oliveira, Antonio Mateus de Jesus…[et al.]. Investigation of Lipid Profile and Clinical Manifestations in SCA Children. Disease Markers. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1154109
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154109