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Cognitive Function of Artemisia argyi H. Fermented by Monascus purpureus under TMT-Induced Learning and Memory Deficits in ICR Mice
Joint Authors
Park, Seon Kyeong
Heo, Ho Jin
Ha, Jeong Su
Kang, Jin Yong
Lee, Du Sang
Kim, Jong Min
Ha, Gi Jeong
Seo, Weon Taek
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-09-10
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
The cognitive effect of Artemisia argyi H.
under liquid-state fermentation by Monascus purpureus (AAFM), which has cellular antioxidant activity and neuronal cell viability, on trimethyltin- (TMT-) induced learning and memory impairment in Institute of Cancer Research (ICR) mice was confirmed.
Tests were conducted to determine the neuroprotective effects against H2O2-induced oxidative stress, and the results showed that AAFM has protective effects through the repression of mitochondrial injury and cellular membrane damage against H2O2-induced neurotoxicity.
In animal experiments, such as the Y-maze, passive avoidance, and Morris water maze tests, AAFM also showed excellent ameliorating effects on TMT-induced cognitive dysfunction.
After behavioral tests, brain tissues were extracted to assess damage to brain tissue.
According to the experimental results, AAFM improved the cholinergic system by upregulating acetylcholine (ACh) contents and inhibiting acetylcholinesterase (AChE) activity.
AAFM effectively improved the decline of the superoxide dismutase (SOD) level and the increase of the oxidized glutathione (GSH) ratio and lipid peroxidation (malondialdehyde (MDA) production) caused by TMT-induced oxidative stress.
The occurrence of mitochondrial dysfunction and apoptosis was also decreased compared with the TMT group.
Finally, quinic acid derivatives were identified as the major phenolic compounds in AAFM using ultra-performance liquid chromatography quadrupole-time-of-flight (UPLC-Q-TOF) MS analysis.
American Psychological Association (APA)
Kang, Jin Yong& Lee, Du Sang& Park, Seon Kyeong& Ha, Jeong Su& Kim, Jong Min& Ha, Gi Jeong…[et al.]. 2017. Cognitive Function of Artemisia argyi H. Fermented by Monascus purpureus under TMT-Induced Learning and Memory Deficits in ICR Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1154118
Modern Language Association (MLA)
Kang, Jin Yong…[et al.]. Cognitive Function of Artemisia argyi H. Fermented by Monascus purpureus under TMT-Induced Learning and Memory Deficits in ICR Mice. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-16.
https://search.emarefa.net/detail/BIM-1154118
American Medical Association (AMA)
Kang, Jin Yong& Lee, Du Sang& Park, Seon Kyeong& Ha, Jeong Su& Kim, Jong Min& Ha, Gi Jeong…[et al.]. Cognitive Function of Artemisia argyi H. Fermented by Monascus purpureus under TMT-Induced Learning and Memory Deficits in ICR Mice. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1154118
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154118