A Novel Gene Signature to Predict Survival Time and Incident Ventricular Arrhythmias in Patients with Dilated Cardiomyopathy
Joint Authors
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-09-15
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The mortality in nonischaemic dilated cardiomyopathy (NIDCM) patients is still at a high level; sudden death in NIDCM can be caused by ventricular tachycardia.
It is necessary to explore the pathogenesis of ventricular arrhythmias (VA) in NIDCM.
Differentially expressed genes (DEGs) were identified by comparing the gene expression of NIDCM patients with or without VA in the gene expression profile of GSE135055.
A total of 228 DEGs were obtained, and 3 genes were screened out to be significantly related to the survival time of NIDCM patients.
We established a prediction model on two-gene (TOMM22, PPP2R5A) signature for the survival time of NIDCM patients.
The area under the curve (AUC) was 0.75 calculated by the ROC curve analysis.
These risk genes are probably new targets for exploring the pathogenesis of NIDCM with VA; the prediction model for survival time and incident ventricular arrhythmias is useful in clinical decision making for individual treatment.
American Psychological Association (APA)
Ge, Chenliang& He, Yan. 2020. A Novel Gene Signature to Predict Survival Time and Incident Ventricular Arrhythmias in Patients with Dilated Cardiomyopathy. Disease Markers،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1154122
Modern Language Association (MLA)
Ge, Chenliang& He, Yan. A Novel Gene Signature to Predict Survival Time and Incident Ventricular Arrhythmias in Patients with Dilated Cardiomyopathy. Disease Markers No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1154122
American Medical Association (AMA)
Ge, Chenliang& He, Yan. A Novel Gene Signature to Predict Survival Time and Incident Ventricular Arrhythmias in Patients with Dilated Cardiomyopathy. Disease Markers. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1154122
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154122