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Pharmacogenomics Study for Raloxifene in Postmenopausal Female with Osteoporosis
Joint Authors
Chou, Po-Hsin
Lin, Gan-Hong
Chou, Wan-Hsuan
Wang, Shih-Tien
Adikusuma, Wirawan
Mugiyanto, Eko
Hung, Kuo-Sheng
Chang, Wei-Chiao
Lu, Hsing-Fang
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-31
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Osteoporosis is characterized by decreased bone mineral density and increased risk of fracture.
Raloxifene is one of the treatments of osteoporosis.
However, the responses were variable among patients.
Previous studies revealed that the genetic variants are involved in the regulation of treatment outcomes.
To date, studies that evaluate the influence of genes across all genome on the raloxifene treatment response are still limited.
In this study, a total of 41 postmenopausal osteoporosis patients under regular raloxifene treatment were included.
Gene-based analysis using MAGMA was applied to investigate the genetic association with the bone mineral density response to raloxifene at the lumbar spine or femoral neck site.
Results from gene-based analysis indicated several genes (GHRHR, ABHD8, and TMPRSS6) related to the responses of raloxifene.
Besides, the pathways of iron ion homeostasis, osteoblast differentiation, and platelet morphogenesis were enriched which implies that these pathways might be relatively susceptible to raloxifene treatment outcome.
Our study provided a novel insight into the response to raloxifene.
American Psychological Association (APA)
Lu, Hsing-Fang& Chou, Po-Hsin& Lin, Gan-Hong& Chou, Wan-Hsuan& Wang, Shih-Tien& Adikusuma, Wirawan…[et al.]. 2020. Pharmacogenomics Study for Raloxifene in Postmenopausal Female with Osteoporosis. Disease Markers،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1154141
Modern Language Association (MLA)
Lu, Hsing-Fang…[et al.]. Pharmacogenomics Study for Raloxifene in Postmenopausal Female with Osteoporosis. Disease Markers No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1154141
American Medical Association (AMA)
Lu, Hsing-Fang& Chou, Po-Hsin& Lin, Gan-Hong& Chou, Wan-Hsuan& Wang, Shih-Tien& Adikusuma, Wirawan…[et al.]. Pharmacogenomics Study for Raloxifene in Postmenopausal Female with Osteoporosis. Disease Markers. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1154141
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154141