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Identification of snoRNA SNORA71A as a Novel Biomarker in Prognosis of Hepatocellular Carcinoma
Joint Authors
Xu, Hao
Ding, Yuan
Zhou, Dongkai
Han, Xin
Ge, Yao
Ding, Hao
Xu, Chang
Sun, Zhongquan
Zhang, Sitong
Zhou, Liuzhi
Xu, Qianhui
Wang, Weilin
Bai, Yang
Li, Yanjie
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-09-27
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Small nucleolar RNAs (snoRNAs) have been proved to play important roles in various cellular physiological process.
Recently, dysregulation of snoRNA SNORA71A has been found involved in tumorigenesis of various malignant cancers.
However, the emerging effects of SNORA71A in hepatocellular carcinoma (HCC) remain largely unclear.
In this study, we aimed to explore the SNORA71A expression and its underlying significance in HCC.
Methods.
Expression of SNORA71A in cell lines and clinical specimens was measured by quantitative real-time PCR.
Then, all enrolled HCC patients were divided into low and high SNORA71A expression subgroups and then they were compared in the aspects of clinical features as well as survival outcome by respective statistical analysis methods.
Results.
SNORA71A was significantly downexpressed in SK-HEP-1 (P=0.001), Huh-7 (P<0.001), Hep3B (P<0.001), and clinical HCC specimens (P=0.006).
Comparing the clinical features between SNORA71A expression subgroups, it showed that low SNORA71A expression was significantly associated with large tumor diameter, multiple lesions, capsular invasion, bad tumor differentiation, and TNM stage (P<0.05).
Furthermore, it was found that HCC patients with lower SNORA71A expression had higher risk in postoperative tumor relapse (median time: 9.5 vs.
35.2 months; low vs.
high; P<0.001) and poor overall survival (median time: 36.8 vs.
52.9 months; low vs.
high; P<0.001).
Besides, SNORA71A expression served as independent risk factors for tumor-free (HR=0.450; 95% CI [0.263-0.770]; P=0.004) and long-term survival (HR=0.289; 95% CI [0.127-0.657]; P=0.003).
Conclusions.
Our study for the first time demonstrated that downregulation of SNORA71A could serve as a novel biomarker for clinical assessment and prognostic prediction of HCC patients.
American Psychological Association (APA)
Ding, Yuan& Sun, Zhongquan& Zhang, Sitong& Zhou, Liuzhi& Xu, Qianhui& Zhou, Dongkai…[et al.]. 2020. Identification of snoRNA SNORA71A as a Novel Biomarker in Prognosis of Hepatocellular Carcinoma. Disease Markers،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1154165
Modern Language Association (MLA)
Ding, Yuan…[et al.]. Identification of snoRNA SNORA71A as a Novel Biomarker in Prognosis of Hepatocellular Carcinoma. Disease Markers No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1154165
American Medical Association (AMA)
Ding, Yuan& Sun, Zhongquan& Zhang, Sitong& Zhou, Liuzhi& Xu, Qianhui& Zhou, Dongkai…[et al.]. Identification of snoRNA SNORA71A as a Novel Biomarker in Prognosis of Hepatocellular Carcinoma. Disease Markers. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1154165
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154165