Kangfuxinye Enema Combined with Mesalamine for Ulcerative Colitis: A Systematic Review and GRADE Approach
Joint Authors
Kang, Deying
Hong, Qi
Ren, Peng-wei
Yang, Wen-jie
Wang, Dan-dan
Shan, Jing-yan
Wen, Shu
Zhang, Ru-wen
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-07
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Objectives.
To critically appraise the efficacy and safety of Kangfuxinye enema combined with mesalamine for the ulcerative colitis (UC) patients and in addition to grade the quality of evidence by using the GRADE (grading of recommendations, assessment, development, and evaluation) approach.
Methods.
A literature search was performed in the Cochrane Library, MEDLINE, EMBASE, CBM, CNKI, VIP, and WanFang Databases.
The search restrictions were patients with UC and RCTs.
Studies including other treatments except Kangfuxinye with mesalamine were excluded.
Results.
Nineteen studies met the inclusion criteria.
We found significant benefits of Kangfuxinye combined with mesalamine against mesalamine alone in improving response rate as well as reducing the recurrence rate and inflammation rate; meanwhile, the increase of the adverse events rate was not observed.
Furthermore, the symptoms remission rate and the cure time were insignificant statistically.
Additionally, GRADE results indicated that the quality of evidence regarding the above 6 outcomes was rated from very low to moderate quality.
Conclusions.
Although Kangfuxinye enema seems effective and safe for treating UC patients in this systematic review, Kangfuxinye enema combined with mesalamine was weakly recommended due to very low to moderate quality of available evidence by the GRADE approach.
American Psychological Association (APA)
Ren, Peng-wei& Yang, Wen-jie& Wang, Dan-dan& Shan, Jing-yan& Kang, Deying& Hong, Qi…[et al.]. 2017. Kangfuxinye Enema Combined with Mesalamine for Ulcerative Colitis: A Systematic Review and GRADE Approach. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1154170
Modern Language Association (MLA)
Ren, Peng-wei…[et al.]. Kangfuxinye Enema Combined with Mesalamine for Ulcerative Colitis: A Systematic Review and GRADE Approach. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-15.
https://search.emarefa.net/detail/BIM-1154170
American Medical Association (AMA)
Ren, Peng-wei& Yang, Wen-jie& Wang, Dan-dan& Shan, Jing-yan& Kang, Deying& Hong, Qi…[et al.]. Kangfuxinye Enema Combined with Mesalamine for Ulcerative Colitis: A Systematic Review and GRADE Approach. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1154170
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154170