Parasite Killing of Leishmania (V) braziliensis by Standardized Propolis Extracts
Joint Authors
Berretta, Andresa Aparecida
Rebouças-Silva, Jéssica
Celes, Fabiana S.
Lima, Jonilson Berlink
de Oliveira, Camila I.
Barud, Hernane da Silva
Borges, Valéria Matos
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-13
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Treatments based on antimonials to cutaneous leishmaniasis (CL) entail a range of toxic side effects.
Propolis, a natural compound widely used in traditional medical applications, exhibits a range of biological effects, including activity against infectious agents.
The aim of this study was to test the potential leishmanicidal effects of different propolis extracts against Leishmania (Viannia) braziliensis promastigotes and intracellular amastigotes in vitro.
Stationary-phase L.
(V) braziliensis promastigotes were incubated with medium alone or treated with dry, alcoholic, or glycolic propolis extract (10, 50, or 100 μg/mL) for 96 h.
Our data showed that all extracts exhibited a dose-dependent effect on the viability of L.
(V) braziliensis promastigotes, while controlling the parasite burden inside infected macrophages.
Dry propolis extract significantly modified the inflammatory profile of murine macrophages by downmodulating TGF-β and IL-10 production, while upmodulating TNF-α.
All three types of propolis extract were found to reduce nitric oxide and superoxide levels in activated L.
braziliensis-infected macrophages.
Altogether, our results showed that propolis extracts exhibited a leishmanicidal effect against both stages of L.
(V) braziliensis.
The low cell toxicity and efficient microbicidal effect of alcoholic or glycolic propolis extracts make them candidates to an additive treatment for cutaneous leishmaniasis.
American Psychological Association (APA)
Rebouças-Silva, Jéssica& Celes, Fabiana S.& Lima, Jonilson Berlink& Barud, Hernane da Silva& de Oliveira, Camila I.& Berretta, Andresa Aparecida…[et al.]. 2017. Parasite Killing of Leishmania (V) braziliensis by Standardized Propolis Extracts. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1154194
Modern Language Association (MLA)
Rebouças-Silva, Jéssica…[et al.]. Parasite Killing of Leishmania (V) braziliensis by Standardized Propolis Extracts. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-14.
https://search.emarefa.net/detail/BIM-1154194
American Medical Association (AMA)
Rebouças-Silva, Jéssica& Celes, Fabiana S.& Lima, Jonilson Berlink& Barud, Hernane da Silva& de Oliveira, Camila I.& Berretta, Andresa Aparecida…[et al.]. Parasite Killing of Leishmania (V) braziliensis by Standardized Propolis Extracts. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1154194
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154194