Exosomes in Nephropathies: A Rich Source of Novel Biomarkers
Joint Authors
Masaoutis, Christos
Al Besher, Samer
Theocharis, Stamatios
Koutroulis, Ioannis
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-12
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The biomarkers commonly utilized in diagnostic evaluations of kidney disease suffer from low sensitivity, especially in the early stages of renal damage.
On the other hand, obtaining a renal biopsy to augment clinical decision making can lead to potentially serious complications.
In order to overcome the shortcomings of currently available diagnostic tools, recent studies suggest that exosomes, cell-secreted extracellular vesicles containing a large array of active molecules to facilitate cell-to-cell communication, may represent a rich source of novel disease biomarkers.
Because of their endocytic origin, exosomes carry markers typical for their parent cells, which could permit the localization of biochemical cellular alterations in specific kidney compartments.
Different types of exosomes can be isolated from noninvasively obtained biofluids; however, in the context of kidney disease, evidence has emerged on the role of urinary exosomes in the diagnostic and predictive modeling of renal pathology.
The current review summarizes the potential application of exosomes in the detection of acute and chronic inflammatory, metabolic, degenerative, and genetic renal diseases.
American Psychological Association (APA)
Masaoutis, Christos& Al Besher, Samer& Koutroulis, Ioannis& Theocharis, Stamatios. 2020. Exosomes in Nephropathies: A Rich Source of Novel Biomarkers. Disease Markers،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1154195
Modern Language Association (MLA)
Masaoutis, Christos…[et al.]. Exosomes in Nephropathies: A Rich Source of Novel Biomarkers. Disease Markers No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1154195
American Medical Association (AMA)
Masaoutis, Christos& Al Besher, Samer& Koutroulis, Ioannis& Theocharis, Stamatios. Exosomes in Nephropathies: A Rich Source of Novel Biomarkers. Disease Markers. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1154195
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154195