Barley Seedling Extracts Inhibit RANKL-Induced Differentiation, Fusion, and Maturation of Osteoclasts in the Early-to-Late Stages of Osteoclastogenesis
Joint Authors
Choi, Sik-Won
Kim, Shin-Hye
Lee, Kwang-Sik
Kang, Hyeon Jung
Lee, Mi Ja
Park, Kie-In
Lee, Jin Hwan
Park, Ki Do
Seo, Woo Duck
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-08
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The number of patients with osteoporosis is increasing worldwide, and a decrease in bone mass is a main risk factor for fracture.
The prevention of bone loss is critical for improving the quality of life for patients.
However, the long-term use of antiosteoporotic agents is limited due to their side effects.
Barley has been traditionally ingested for thousands of years as a safe, natural food with pharmaceutical properties, and its seedling can enhance the biological activity of the medicinal components found in food.
This study aimed to clarify the antiresorptive activity of barley seedling and its mode of action.
Barley seedling extracts (BSE) dose-dependently inhibited RANKL-induced osteoclast differentiation with alteration of IκB degradation, c-Fos, and NFATc1 molecules in the early-to-middle stages of osteoclastogenesis.
In the late phase of osteoclastogenesis, BSE also prevented DC-STAMP and cathepsin K, which are required for cell fusion and bone degradation, such as osteoclast function.
In conclusion, barley seedling from natural foods may provide long-term safety and be useful for the prevention or treatment of osteoclast-mediated bone metabolic diseases, including osteoporosis.
American Psychological Association (APA)
Choi, Sik-Won& Kim, Shin-Hye& Lee, Kwang-Sik& Kang, Hyeon Jung& Lee, Mi Ja& Park, Kie-In…[et al.]. 2017. Barley Seedling Extracts Inhibit RANKL-Induced Differentiation, Fusion, and Maturation of Osteoclasts in the Early-to-Late Stages of Osteoclastogenesis. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1154199
Modern Language Association (MLA)
Choi, Sik-Won…[et al.]. Barley Seedling Extracts Inhibit RANKL-Induced Differentiation, Fusion, and Maturation of Osteoclasts in the Early-to-Late Stages of Osteoclastogenesis. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1154199
American Medical Association (AMA)
Choi, Sik-Won& Kim, Shin-Hye& Lee, Kwang-Sik& Kang, Hyeon Jung& Lee, Mi Ja& Park, Kie-In…[et al.]. Barley Seedling Extracts Inhibit RANKL-Induced Differentiation, Fusion, and Maturation of Osteoclasts in the Early-to-Late Stages of Osteoclastogenesis. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1154199
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154199