A Systematic Review of Intervention Studies Examining Nutritional and Herbal Therapies for Mild Cognitive Impairment and Dementia Using Neuroimaging Methods: Study Characteristics and Intervention Efficacy
Joint Authors
Huang, Yong
Chang, Dennis
Steiner, Genevieve
Mathersul, Danielle C.
Seto, Sai Wang
MacMillan, Freya
Klupp, Nerida L.
Hohenberg, Mark I.
Camfield, D. A.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-21, 21 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-19
Country of Publication
Egypt
No. of Pages
21
Main Subjects
Abstract EN
Neuroimaging facilitates the assessment of complementary medicines (CMs) by providing a noninvasive insight into their mechanisms of action in the human brain.
This is important for identifying the potential treatment options for target disease cohorts with complex pathophysiologies.
The aim of this systematic review was to evaluate study characteristics, intervention efficacy, and the structural and functional neuroimaging methods used in research assessing nutritional and herbal medicines for mild cognitive impairment (MCI) and dementia.
Six databases were searched for articles reporting on CMs, dementia, and neuroimaging methods.
Data were extracted from 21/2,742 eligible full text articles and risk of bias was assessed.
Nine studies examined people with Alzheimer’s disease, 7 MCI, 4 vascular dementia, and 1 all-cause dementia.
Ten studies tested herbal medicines, 8 vitamins and supplements, and 3 nootropics.
Ten studies used electroencephalography (EEG), 5 structural magnetic resonance imaging (MRI), 2 functional MRI (fMRI), 3 cerebral blood flow (CBF), 1 single photon emission tomography (SPECT), and 1 positron emission tomography (PET).
Four studies had a low risk of bias, with the majority consistently demonstrating inadequate reporting on randomisation, allocation concealment, blinding, and power calculations.
A narrative synthesis approach was assumed due to heterogeneity in study methods, interventions, target cohorts, and quality.
Eleven key recommendations are suggested to advance future work in this area.
American Psychological Association (APA)
Steiner, Genevieve& Mathersul, Danielle C.& MacMillan, Freya& Camfield, D. A.& Klupp, Nerida L.& Seto, Sai Wang…[et al.]. 2017. A Systematic Review of Intervention Studies Examining Nutritional and Herbal Therapies for Mild Cognitive Impairment and Dementia Using Neuroimaging Methods: Study Characteristics and Intervention Efficacy. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-21.
https://search.emarefa.net/detail/BIM-1154201
Modern Language Association (MLA)
Steiner, Genevieve…[et al.]. A Systematic Review of Intervention Studies Examining Nutritional and Herbal Therapies for Mild Cognitive Impairment and Dementia Using Neuroimaging Methods: Study Characteristics and Intervention Efficacy. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-21.
https://search.emarefa.net/detail/BIM-1154201
American Medical Association (AMA)
Steiner, Genevieve& Mathersul, Danielle C.& MacMillan, Freya& Camfield, D. A.& Klupp, Nerida L.& Seto, Sai Wang…[et al.]. A Systematic Review of Intervention Studies Examining Nutritional and Herbal Therapies for Mild Cognitive Impairment and Dementia Using Neuroimaging Methods: Study Characteristics and Intervention Efficacy. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-21.
https://search.emarefa.net/detail/BIM-1154201
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154201