A Systematic Review and Meta-Analysis for the Association of Gene Polymorphisms in RAN with Cancer Risk
Joint Authors
Xing, Chengzhong
Li, Yanke
Zhang, Fuqiang
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-01-16
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
As an important component of miRNA processing genes, RAN gene encodes the ras-related nuclear protein, which is a unique member of the Ras superfamily of GTPases.
The mutations in RAN gene are very likely to play a critical role in pathology-related changes to miRNA transport and expression and thus participate in tumor genesis and development.
Currently, accumulating studies have explored the association between RAN SNPs and cancer risk.
However, the results are conflicting.
In the present study, we performed a systematic review for the association of RAN SNPs with overall cancer risk.
Meanwhile, a meta-analysis was conducted based on available data, aiming at clarifying the association between RAN SNPs and cancer susceptibility.
After literature search and data extraction, 17 studies containing four RAN SNPs were involved in the systematic review.
And 12 studies with two highly studied SNPs (RAN rs14035 C>T and rs3803012 A>G) were included in the final meta-analysis, consisting of 7662 cases and 9807 controls.
The results showed that the rs14035 polymorphism was linked to a decreased cancer risk in overall subjects and hospital-based (HB) subgroup, while the rs3803012 polymorphism conferred to an increased cancer risk in overall subjects and population-based (PB) subgroup.
Our findings suggested that the two SNPs had the potential to be predictive biomarkers for cancer risk.
The study would provide novel clues for the identification of miRNA-related genetic biomarkers applied to predicting cancer susceptibility.
American Psychological Association (APA)
Li, Yanke& Zhang, Fuqiang& Xing, Chengzhong. 2020. A Systematic Review and Meta-Analysis for the Association of Gene Polymorphisms in RAN with Cancer Risk. Disease Markers،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1154206
Modern Language Association (MLA)
Li, Yanke…[et al.]. A Systematic Review and Meta-Analysis for the Association of Gene Polymorphisms in RAN with Cancer Risk. Disease Markers No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1154206
American Medical Association (AMA)
Li, Yanke& Zhang, Fuqiang& Xing, Chengzhong. A Systematic Review and Meta-Analysis for the Association of Gene Polymorphisms in RAN with Cancer Risk. Disease Markers. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1154206
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154206