![](/images/graphics-bg.png)
Spatholobus suberectus Exhibits Antidiabetic Activity In Vitro and In Vivo through Activation of AKT-AMPK Pathway
Joint Authors
Lee, Sang-Han
Zhao, Peijun
Alam, Md Badrul
Lee, Seok-hyun
Kim, Young-Jun
Lee, Seul
An, Hongyan
Choi, Hee-Jeong
Son, Hyeong-U
Park, Chul-Hong
Kim, Hyo-Hyun
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-18
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Glucose deposition in peripheral tissue is an important parameter for the treatment of type 2 diabetes mellitus.
The aim of this study was to investigate the effects of Spatholobus suberectus (Ss) on glucose disposal in skeletal muscle cells and additionally explore its in vivo antidiabetic potential.
Treatment of ethanolic extract of S.
suberectus (EeSs) significantly enhanced the glucose uptake, mediated through the enhanced expression of GLUT4 in skeletal muscle via the stimulation of AKT and AMPK pathways in C2C12 cells.
Moreover, EeSs have potential inhibitory action on α-glucosidase activity and significantly lowered the postprandial blood glucose levels in STZ-induced diabetic mice, associated with increased expression of GLUT4 and AKT and/or AMPK-mediated signaling cascade in skeletal muscle.
Furthermore, administration of EeSs significantly boosted up the antioxidant enzyme expression and also mitigated the gluconeogenesis enzyme such as PEPCK and G-6-Pase enzyme expression in liver tissue of STZ-induced diabetic mice model.
Collectively, these findings suggest that EeSs have a high potentiality to mitigate diabetic symptoms through stimulating glucose uptake in peripheral tissue via the activation of AKT and AMPK signaling cascade and augmenting antioxidant potentiality as well as blocking the gluconeogenesis process in diabetic mice.
American Psychological Association (APA)
Zhao, Peijun& Alam, Md Badrul& Lee, Seok-hyun& Kim, Young-Jun& Lee, Seul& An, Hongyan…[et al.]. 2017. Spatholobus suberectus Exhibits Antidiabetic Activity In Vitro and In Vivo through Activation of AKT-AMPK Pathway. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1154209
Modern Language Association (MLA)
Zhao, Peijun…[et al.]. Spatholobus suberectus Exhibits Antidiabetic Activity In Vitro and In Vivo through Activation of AKT-AMPK Pathway. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1154209
American Medical Association (AMA)
Zhao, Peijun& Alam, Md Badrul& Lee, Seok-hyun& Kim, Young-Jun& Lee, Seul& An, Hongyan…[et al.]. Spatholobus suberectus Exhibits Antidiabetic Activity In Vitro and In Vivo through Activation of AKT-AMPK Pathway. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1154209
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154209