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Iridoid Glycosides Fraction Isolated from Veronica ciliata Fisch. Protects against Acetaminophen-Induced Liver Injury in Mice
Joint Authors
Tan, Shancai
Lu, Qiuxia
Shu, Yueyue
Sun, Yiran
Chen, Fang
Tang, Lin
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-13
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Veronica ciliata Fisch.
has traditionally been used in Tibetan medicine for the treatment of hepatitis, cholecystitis, rheumatism, and urticaria.
We analyzed the chemical composition of the iridoid glycosides fraction (IGF) isolated from V.
ciliata and evaluated the antioxidant and hepatoprotective properties.
The IGF was separated by high-speed countercurrent chromatography (HSCCC) and the main compounds were identified by ultra-performance liquid chromatography coupled to a photodiode array.
We determined the in vitro antioxidant ability of the IGF through radical scavenging assays and assessed the in vivo hepatoprotective potential in an acetaminophen- (APAP-) induced acute liver injury murine model.
The IGF was separated by HSCCC and three major iridoid glycosides (verproside, catalposide, and amphicoside) were identified as potent antioxidants and hepatoprotective compounds.
Treatment with the IGF significantly suppressed the APAP-induced elevation in serum alanine aminotransferase, aspartate aminotransferase, and tumor necrosis factor-alpha (TNF-α); improved serum total antioxidant capacity; decreased malondialdehyde formation; elevated superoxide dismutase and glutathione activity; and decreased expression of proinflammatory factors (TNF-α, nuclear factor kappa B) in the liver.
Finally, we examined the histopathology of resected livers for evidence of hepatoprotection.
The protection conferred by the IGF may be related to the reinforcement of antioxidant defense systems.
American Psychological Association (APA)
Tan, Shancai& Lu, Qiuxia& Shu, Yueyue& Sun, Yiran& Chen, Fang& Tang, Lin. 2017. Iridoid Glycosides Fraction Isolated from Veronica ciliata Fisch. Protects against Acetaminophen-Induced Liver Injury in Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1154214
Modern Language Association (MLA)
Tan, Shancai…[et al.]. Iridoid Glycosides Fraction Isolated from Veronica ciliata Fisch. Protects against Acetaminophen-Induced Liver Injury in Mice. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1154214
American Medical Association (AMA)
Tan, Shancai& Lu, Qiuxia& Shu, Yueyue& Sun, Yiran& Chen, Fang& Tang, Lin. Iridoid Glycosides Fraction Isolated from Veronica ciliata Fisch. Protects against Acetaminophen-Induced Liver Injury in Mice. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1154214
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154214