Genetic Polymorphisms of MMP1, MMP9, COL1A1, and COL1A2 in Polish Patients with Thoracic Aortopathy
Joint Authors
Gorący, Iwona
Grudniewicz, Seweryn
Safranow, Krzysztof
Ciechanowicz, Andrzej
Jakubiszyn, Paweł
Gorący, Anna
Brykczyński, Mirosław
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-09-24
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
The pathogenesis of thoracic aortopathy is complex, and much evidence suggests the influence of genetic factors.
Some genes with polymorphisms are widely considered critical factors in the initiation and development of aortic aneurysm.
The aim of our study was to analyze the association of genetic polymorphisms of MMP1 rs1799750 (c.-1607G>GG), MMP9 rs3918242 (c.-1562C>T), COL1A1 rs1800012 (c.1245G>T), and COL1A2 rs42524 (c.1645G>C) with predisposition to thoracic aortopathy in Polish patients and with clinical characteristics of these patients.
Methods.
The study was carried out with 96 patients with thoracic aortopathy (47 patients with ascending aortic aneurysm and 49 patients with thoracic aortic dissection) and 61 control subjects without thoracic aortopathy.
The MMP1, MMP9, COL1A1, and COL1A2 polymorphisms were determined by PCR-RFLP.
Results.
No significant differences in the frequency distributions of MMP1, MMP9, COL1A1, and COL1A2 genotypes or alleles were found (1) between the control group and patients with ascending aortic aneurysm (AsAA), (2) between the control group and patients with thoracic aortic dissection (TAD), or (3) between AsAA and TAD patients.
Multivariate logistic regression analysis revealed that MMP1 and MMP9 polymorphisms were associated with the degree of aortic valve regurgitation.
Conclusion.
The results of our study did not support associations between MMP1, MMP9, COL1A1, and COL1A2 genetic variants with the risk of thoracic artery disease in Polish patients.
However, rs1799750 MMP1 and rs3918242 MMP9 seem to be associated with the degree of aortic regurgitation.
American Psychological Association (APA)
Gorący, Iwona& Grudniewicz, Seweryn& Safranow, Krzysztof& Ciechanowicz, Andrzej& Jakubiszyn, Paweł& Gorący, Anna…[et al.]. 2020. Genetic Polymorphisms of MMP1, MMP9, COL1A1, and COL1A2 in Polish Patients with Thoracic Aortopathy. Disease Markers،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1154227
Modern Language Association (MLA)
Gorący, Iwona…[et al.]. Genetic Polymorphisms of MMP1, MMP9, COL1A1, and COL1A2 in Polish Patients with Thoracic Aortopathy. Disease Markers No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1154227
American Medical Association (AMA)
Gorący, Iwona& Grudniewicz, Seweryn& Safranow, Krzysztof& Ciechanowicz, Andrzej& Jakubiszyn, Paweł& Gorący, Anna…[et al.]. Genetic Polymorphisms of MMP1, MMP9, COL1A1, and COL1A2 in Polish Patients with Thoracic Aortopathy. Disease Markers. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1154227
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154227