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Pharmacodynamics and Medicinal Chemistry of an External Chinese Herbal Formula for Mammary Precancerous Lesions
Joint Authors
Ma, Yi
Ma, Min
Chen, Ruixue
Bie, Fengjie
Zhang, Guijuan
Fan, Hongxia
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-24
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Ruyan Neixiao Cream (RYNXC) is a traditional Chinese herbal formula for treating mammary precancerous disease.
This study was carried out to investigate in vivo anticancer effect of RYNXC and multiple constituents.
32 virginal Sprague-Dawley rats were randomly divided into blank control group (BC), mammary precancer models group (MODEL), tamoxifen group (TAM), and Ruyan Neixiao Cream group (RYNXC).
TAM was intervened by tamoxifen; RYNXC was intervened by Ruyan Neixiao Cream.
The chromatographic separation was performed by high performance liquid chromatography (HPLC) coupled with mass spectrometry (MS).
RYNXC showed significant improvement in erythrocyte aggregation index (EAI), hematocrit (HCT), fibrinogen (FIB), spleen coefficient, and uterus coefficient compared with MODEL.
In RYNXC and TAM groups, atypical hyperplasia was observed in pathological mammary tissues; meanwhile in MODEL group, ductal carcinoma was observed in situ.
Moreover, fifteen compounds were characterized according to HPLC-MS data, including organic acids, tannin, alkaloid, volatile oil, anthraquinones, and flavonoids.
The study suggests that RYNXC was an effective Chinese herbal formula for mammary precancerous lesions and provides a scientific basis for the quality standard and the pharmacology of RYNXC.
It will be beneficial to the future clinical application of RYNXC.
American Psychological Association (APA)
Chen, Ruixue& Zhang, Guijuan& Ma, Yi& Bie, Fengjie& Fan, Hongxia& Ma, Min. 2017. Pharmacodynamics and Medicinal Chemistry of an External Chinese Herbal Formula for Mammary Precancerous Lesions. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1154231
Modern Language Association (MLA)
Chen, Ruixue…[et al.]. Pharmacodynamics and Medicinal Chemistry of an External Chinese Herbal Formula for Mammary Precancerous Lesions. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1154231
American Medical Association (AMA)
Chen, Ruixue& Zhang, Guijuan& Ma, Yi& Bie, Fengjie& Fan, Hongxia& Ma, Min. Pharmacodynamics and Medicinal Chemistry of an External Chinese Herbal Formula for Mammary Precancerous Lesions. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1154231
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154231