Aqueous Extracts of Herba Cistanche Promoted Intestinal Motility in Loperamide-Induced Constipation Rats by Ameliorating the Interstitial Cells of Cajal
Joint Authors
Wu, Bensheng
Wang, Xiaopeng
Yan, Shuai
Yue, Yin-zi
Dong, Hong-li
Zhen, Shu-guang
Qian, Hai-hua
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-28
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Traditional Chinese medicine was reported to have good effects in treating functional constipation.
This work attempted to prove the effects of aqueous extracts of Herba Cistanche (AEHC) on STC treatment and to determine the possible mechanisms by a loperamide-induced slow transit constipation (STC) model.
HPLC was performed for identification and confirmation of the bioactive components in the AEHC.
It was found that AEHC attenuated STC responses based on increased fecal quantity, moisture content, and intestinal transit rate, as well as serum levels of GAS, MTL, SS, and CGRP.
The protein and mRNA levels of c-kit, a labeling of interstitial cells of Cajal (ICC), also increased.
Meanwhile, only the protein level of SCF, a ligand of c-kit, increased.
The analysis of our data suggested that AEHC could obviously improve the function of ICC via a signaling pathway involving PI3K, SCF, and c-kit and enhance colonic motility indices such as GAS, MTL, SS, and CGRP.
It is interesting to note that AEHC appeared to be effective on constipation, so further experiments are necessary to clarify the exact mechanisms involved.
American Psychological Association (APA)
Yan, Shuai& Yue, Yin-zi& Wang, Xiaopeng& Dong, Hong-li& Zhen, Shu-guang& Wu, Bensheng…[et al.]. 2017. Aqueous Extracts of Herba Cistanche Promoted Intestinal Motility in Loperamide-Induced Constipation Rats by Ameliorating the Interstitial Cells of Cajal. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1154235
Modern Language Association (MLA)
Yan, Shuai…[et al.]. Aqueous Extracts of Herba Cistanche Promoted Intestinal Motility in Loperamide-Induced Constipation Rats by Ameliorating the Interstitial Cells of Cajal. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1154235
American Medical Association (AMA)
Yan, Shuai& Yue, Yin-zi& Wang, Xiaopeng& Dong, Hong-li& Zhen, Shu-guang& Wu, Bensheng…[et al.]. Aqueous Extracts of Herba Cistanche Promoted Intestinal Motility in Loperamide-Induced Constipation Rats by Ameliorating the Interstitial Cells of Cajal. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1154235
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154235