Chinese Herbal Medicine Baoyuan Jiedu Decoction Inhibited Muscle Atrophy of Cancer Cachexia through Atrogin-l and MuRF-1
Joint Authors
Ji, Xu-Ming
Han, Xiao-Chun
Zhang, YaNan
Ouyang, Bing
Wu, ZhiChun
Yu, HuaYun
Wang, Yuan
Liu, GuoWei
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-14
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The aim of this study is to investigate the mechanisms of Chinese herbal medicine called “Baoyuan Jiedu” (BYJD for short) decoction, improving life quality and preventing muscle atrophy of cancer cachexia model mice.
We showed that the effect of BYJD decoction increased body weights of mice and reduced tumor volume and tumor mass.
Furthermore, BYJD decoction increased the gastrocnemii mass and the transverse diameter of muscle fiber morphology.
Moreover, BYJD reduced the expression of Atrogin-1 and MuRF-1 protein.
Collectively, our results show that BYJD decoction improves the life quality of cancer cachexia mice and prevents muscle atrophy by downregulating expression of Atrogin-1 and MuRF-1.
American Psychological Association (APA)
Zhang, YaNan& Han, Xiao-Chun& Ouyang, Bing& Wu, ZhiChun& Yu, HuaYun& Wang, Yuan…[et al.]. 2017. Chinese Herbal Medicine Baoyuan Jiedu Decoction Inhibited Muscle Atrophy of Cancer Cachexia through Atrogin-l and MuRF-1. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1154245
Modern Language Association (MLA)
Zhang, YaNan…[et al.]. Chinese Herbal Medicine Baoyuan Jiedu Decoction Inhibited Muscle Atrophy of Cancer Cachexia through Atrogin-l and MuRF-1. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1154245
American Medical Association (AMA)
Zhang, YaNan& Han, Xiao-Chun& Ouyang, Bing& Wu, ZhiChun& Yu, HuaYun& Wang, Yuan…[et al.]. Chinese Herbal Medicine Baoyuan Jiedu Decoction Inhibited Muscle Atrophy of Cancer Cachexia through Atrogin-l and MuRF-1. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1154245
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154245