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Combination Therapy with 1% Nanocurcumin Gel and 0.1% Triamcinolone Acetonide Mouth Rinse for Oral Lichen Planus: A Randomized Double-Blind Placebo Controlled Clinical Trial
Joint Authors
Bakhshi, Mahin
Mahboubi, Arash
Gholami, Shahzad
Namdari, Mahshid
Jafari, Mahmoud Reza
Source
Dermatology Research and Practice
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-20
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objectives.
This study aimed to evaluate the efficacy of a combination of 1% nanocurcumin gel with 0.1% triamcinolone acetonide mouth rinse for oral lichen planus (OLP).
Materials and Methods.
This double-blind randomized clinical trial was conducted on 31 patients with erosive or ulcerative OLP.
All patients received 0.1% triamcinolone mouth rinse and were then randomly divided into two groups for combination therapy with (I) %1 nanocurcumin gel or (II) placebo gel.
The reticular-erosive-ulcerative (REU) score was calculated at baseline and at two and four weeks after the intervention.
The changes in the mean REU score and the efficacy index were calculated to determine the level of improvement after two and four weeks.
Data were analyzed using independent t-test, repeated measures ANCOVA, Mann–Whitney test, and chi-square test.
P<0.05 was considered statistically significant.
Results.
There were 14 patients in the nanocurcumin and 17 patients in the placebo group.
A significantly higher decrease in the mean REU score was observed in the nanocurcumin compared with the placebo group (P<0.001).
The efficacy index was significantly higher in the nanocurcumin group (P<0.001).
Conclusion.
Application of 1% nanocurcumin in combination with 0.1% triamcinolone acetonide can serve as an effective treatment strategy to enhance the level of improvement of lesions compared with the use of triamcinolone acetonide alone.
American Psychological Association (APA)
Bakhshi, Mahin& Gholami, Shahzad& Mahboubi, Arash& Jafari, Mahmoud Reza& Namdari, Mahshid. 2020. Combination Therapy with 1% Nanocurcumin Gel and 0.1% Triamcinolone Acetonide Mouth Rinse for Oral Lichen Planus: A Randomized Double-Blind Placebo Controlled Clinical Trial. Dermatology Research and Practice،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1154272
Modern Language Association (MLA)
Bakhshi, Mahin…[et al.]. Combination Therapy with 1% Nanocurcumin Gel and 0.1% Triamcinolone Acetonide Mouth Rinse for Oral Lichen Planus: A Randomized Double-Blind Placebo Controlled Clinical Trial. Dermatology Research and Practice No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1154272
American Medical Association (AMA)
Bakhshi, Mahin& Gholami, Shahzad& Mahboubi, Arash& Jafari, Mahmoud Reza& Namdari, Mahshid. Combination Therapy with 1% Nanocurcumin Gel and 0.1% Triamcinolone Acetonide Mouth Rinse for Oral Lichen Planus: A Randomized Double-Blind Placebo Controlled Clinical Trial. Dermatology Research and Practice. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1154272
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154272