Antihypercholesterolemic Effects of Fruit Aqueous Extract of Copernicia prunifera (Miller) H. E. Moore in Mice Diet-Induced Hypercholesterolemia
Joint Authors
Vieira, Ícaro Gusmão Pinto
Guedes, Maria Izabel Florindo
Paim, Raquel Teixeira Terceiro
Mendes, Francisca Noelia Pereira
Benjamin, Stephen Rathinaraj
Rondina, Davide
Viana, Daniel de Araújo
Marques, Márcia Maria Mendes
Gonzaga, Maria Leônia C.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-11
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
The present objective of the investigation is to evaluate the antihypercholesterolemic activity of the aqueous fruit pulp extract (APE) of Copernicia prunifera (Miller) H.
E.
Moore (Arecaceae family).
Various chemical characterization methods like thin layer chromatography, Fourier transform infrared spectroscopy, 1H and 13C NMR, and molecular weight by gel permeation chromatography have been employed to characterize the extracted pectin.
The present study demonstrated that hypercholesterolemic diet (HD) created hypercholesterolemia, caused significant increases in body weight, total cholesterol, and low-density lipoprotein, and caused decreases in high-density lipoprotein in serum compared with SD group.
Two doses (APE 150 and 300 mg/Kg b.w./day) were administered to hyperlipidemic mice for 90 days.
APE reversed body weight changes, changed serum lipids to normal values, and significantly inhibited the changes of lipid peroxidation and inflammation in the liver tissues.
The renal parameters analyzed (urea and creatinine) altered by diet were reverted to normal values.
Our results revealed that aqueous fruit pulp extracts of carnauba reduced hypercholesterolemia showing a potential preventive effect against cardiovascular diseases without side effects cause.
American Psychological Association (APA)
Paim, Raquel Teixeira Terceiro& Benjamin, Stephen Rathinaraj& Rondina, Davide& Marques, Márcia Maria Mendes& Viana, Daniel de Araújo& Gonzaga, Maria Leônia C.…[et al.]. 2017. Antihypercholesterolemic Effects of Fruit Aqueous Extract of Copernicia prunifera (Miller) H. E. Moore in Mice Diet-Induced Hypercholesterolemia. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1154278
Modern Language Association (MLA)
Paim, Raquel Teixeira Terceiro…[et al.]. Antihypercholesterolemic Effects of Fruit Aqueous Extract of Copernicia prunifera (Miller) H. E. Moore in Mice Diet-Induced Hypercholesterolemia. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-15.
https://search.emarefa.net/detail/BIM-1154278
American Medical Association (AMA)
Paim, Raquel Teixeira Terceiro& Benjamin, Stephen Rathinaraj& Rondina, Davide& Marques, Márcia Maria Mendes& Viana, Daniel de Araújo& Gonzaga, Maria Leônia C.…[et al.]. Antihypercholesterolemic Effects of Fruit Aqueous Extract of Copernicia prunifera (Miller) H. E. Moore in Mice Diet-Induced Hypercholesterolemia. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1154278
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154278