Yacon (Smallanthus sonchifolius) Leaf Extract Attenuates Hyperglycemia and Skeletal Muscle Oxidative Stress and Inflammation in Diabetic Rats
Joint Authors
dos Santos, Klinsmann Carolo
Correa, C. R.
Chen, Chung-Yen Oliver
Bueno, Bianca Guerra
Pereira, Luana Ferreira
Francisqueti, Fabiane Valentini
Braz, Mariana Gobbo
Bincoleto, Lahis Fernandes
Silva, Lilian Xavier da
Ferreira, Ana Lúcia A.
Nakamune, Ana Cláudia de Melo Stevanato
Blumberg, Jeffrey B.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-20
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The effects of hydroethanolic extract of Yacon leaves (HEYL) on antioxidant, glycemic, and inflammatory biomarkers were tested in diabetic rats.
Outcome parameters included glucose, insulin, interleukin-6 (IL-6), and hydrophilic antioxidant capacity (HAC) in serum and IL-6, HAC, malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) in soleus.
The rats (10/group) were divided as follows: C, controls; C + Y, HEYL treated; DM, diabetic controls; and DM + Y, diabetic rats treated with HEYL.
Diabetes mellitus was induced by administration of streptozotocin.
C + Y and DM + Y groups received 100 mg/kg HEYL daily via gavage for 30 d.
Hyperglycemia was improved in the DM + Y versus DM group.
Insulin was reduced in DM versus C group.
DM rats had higher IL-6 and MDA and lower HAC in the soleus muscle.
HEYL treatment decreased IL-6 and MDA and increased HAC in DM rats.
DM + Y rats had the highest CAT activity versus the other groups; GPx was higher in C + Y and DM + Y versus their respective controls.
The apparent benefit of HEYL may be mediated via improving glucoregulation and ameliorating oxidative stress and inflammation, particularly in diabetic rats.
American Psychological Association (APA)
dos Santos, Klinsmann Carolo& Bueno, Bianca Guerra& Pereira, Luana Ferreira& Francisqueti, Fabiane Valentini& Braz, Mariana Gobbo& Bincoleto, Lahis Fernandes…[et al.]. 2017. Yacon (Smallanthus sonchifolius) Leaf Extract Attenuates Hyperglycemia and Skeletal Muscle Oxidative Stress and Inflammation in Diabetic Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1154292
Modern Language Association (MLA)
dos Santos, Klinsmann Carolo…[et al.]. Yacon (Smallanthus sonchifolius) Leaf Extract Attenuates Hyperglycemia and Skeletal Muscle Oxidative Stress and Inflammation in Diabetic Rats. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1154292
American Medical Association (AMA)
dos Santos, Klinsmann Carolo& Bueno, Bianca Guerra& Pereira, Luana Ferreira& Francisqueti, Fabiane Valentini& Braz, Mariana Gobbo& Bincoleto, Lahis Fernandes…[et al.]. Yacon (Smallanthus sonchifolius) Leaf Extract Attenuates Hyperglycemia and Skeletal Muscle Oxidative Stress and Inflammation in Diabetic Rats. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1154292
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154292