GCMS-Based Metabolomics Reveals Biomarkers in Asthma Murine Model Modulated by Opuntia humifusa
Joint Authors
Seo, Seung-Ho
Lee, Soon-Young
Bok, So-Hyeon
Park, Dae-Hun
Byun, Sung-Hoon
Son, Hong-Seok
Kim, Eun-Ju
Park, Seong-Eun
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-11-01
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
GC/MS coupled with multivariate statistical analysis was performed to identify marker metabolites in serum of mice after healing ovalbumin- (OVA-) induced asthma using Opuntia humifusa.
Principal component analysis (PCA) score plot showed separation among groups, with metabolite profiles of serum showing differences according to various treatments for the asthma murine model.
Levels of stearic acid and arachidic acid were significantly lower in the serum from OVA-induced group than those from the control group.
Dexamethasone treatment group was characterized by higher serum levels of urea, myristic acid, and palmitic acid along with lower levels of aspartic acid compared to OVA-induced group.
O.
humifusa treatment mice groups showed dose-proportional higher levels of urea and glycerol than OVA-induced group.
These results highlight that GC/MS-based metabolomics is a powerful technique for identifying molecular markers of asthma.
American Psychological Association (APA)
Seo, Seung-Ho& Kim, Eun-Ju& Park, Seong-Eun& Byun, Sung-Hoon& Lee, Soon-Young& Bok, So-Hyeon…[et al.]. 2018. GCMS-Based Metabolomics Reveals Biomarkers in Asthma Murine Model Modulated by Opuntia humifusa. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1154338
Modern Language Association (MLA)
Seo, Seung-Ho…[et al.]. GCMS-Based Metabolomics Reveals Biomarkers in Asthma Murine Model Modulated by Opuntia humifusa. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1154338
American Medical Association (AMA)
Seo, Seung-Ho& Kim, Eun-Ju& Park, Seong-Eun& Byun, Sung-Hoon& Lee, Soon-Young& Bok, So-Hyeon…[et al.]. GCMS-Based Metabolomics Reveals Biomarkers in Asthma Murine Model Modulated by Opuntia humifusa. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1154338
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154338