Ping-Chong-Jiang-Ni Formula Induces Apoptosis and Inhibits Proliferation of Human Ectopic Endometrial Stromal Cells in Endometriosis via the Activation of JNK Signaling Pathway
Joint Authors
Liang, Rui-Ning
Li, Pei-Shuang
Zou, Yang
Liu, Yu-Ling
Jiang, Zhen
Liu, Zhen
Fan, Pei
Xu, Ling
Peng, Jia-Hua
Sun, Xue-Yan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-01
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Endometriosis is a common gynecological condition in childbearing age women and its therapy in modern medicine achieves usually temporary cure.
Ping-Chong-Jiang-Ni formula (PCJNF), a Chinese herbal medicine (CHM), was shown to be clinically effective on endometriosis.
Meanwhile, c-Jun N-terminal kinase (JNK) signaling pathway was involved in the therapeutic process of CHM on endometriosis.
Here, we explored the effect of PCJNF on the ectopic endometrial stromal cells (EESCs) from endometriosis and test whether JNK signaling was involved.
After being treated with PCJNF-containing serum obtained from Sprague Dawley rat, cell proliferation, migration, invasion, and apoptosis were evaluated in EESCs, and the total and phosphorylated JNK, ERK, and p38 proteins were detected.
Our results showed that PCJNF could suppress cell proliferation, migration, and invasion and induce apoptosis in EESCs.
The suppressed proliferation and increased apoptosis were dependent on JNK activation.
Additionally, PCJNF caused cell cycle arrest at G2/M phase and this effect was mediated by JNK signaling, while the decreased cell migration and invasion treated by PCJNF were independent of JNK signaling.
In summary, our results provided the first evidence that PCJNF could suppress cell proliferation, migration, and invasion, while increasing apoptosis in EESCs, and the suppressed proliferation and enhanced apoptosis were mediated by JNK signaling.
American Psychological Association (APA)
Liang, Rui-Ning& Li, Pei-Shuang& Zou, Yang& Liu, Yu-Ling& Jiang, Zhen& Liu, Zhen…[et al.]. 2017. Ping-Chong-Jiang-Ni Formula Induces Apoptosis and Inhibits Proliferation of Human Ectopic Endometrial Stromal Cells in Endometriosis via the Activation of JNK Signaling Pathway. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1154346
Modern Language Association (MLA)
Liang, Rui-Ning…[et al.]. Ping-Chong-Jiang-Ni Formula Induces Apoptosis and Inhibits Proliferation of Human Ectopic Endometrial Stromal Cells in Endometriosis via the Activation of JNK Signaling Pathway. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1154346
American Medical Association (AMA)
Liang, Rui-Ning& Li, Pei-Shuang& Zou, Yang& Liu, Yu-Ling& Jiang, Zhen& Liu, Zhen…[et al.]. Ping-Chong-Jiang-Ni Formula Induces Apoptosis and Inhibits Proliferation of Human Ectopic Endometrial Stromal Cells in Endometriosis via the Activation of JNK Signaling Pathway. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1154346
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154346