Effect of Sheng-Jiang Powder on Obesity-Induced Multiple Organ Injuries in Rats
Joint Authors
Wan, Mei-Hua
Tang, Wen-Fu
Zhang, Yumei
Li, Juan
Li, Jun-yi
Zhu, Lv
Kang, Hong-xin
Ren, Hong-yu
Chen, Huan
Yuan, Ling
Miao, Yi-fan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-29
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background and Aims.
Obesity has become the main public health issue nowadays with poor control and has been associated with increased risk of multiorgan disease, but the specific mechanism and effective medication are still to be addressed.
Sheng-jiang powder (SJP) showed great potential in preventing obesity in Chinese researches but has no trace in English reports.
This study was designed to investigate the effect of SJP on obesity and obesity-mediated multiorgan injuries.
Methods.
Rats were randomized into normal group (NG), obese group (OG), and SJP treatment group (SG).
Obesity was induced by high-fat diet feeding.
Rats were gavaged with SJP/normal saline daily from the third week and all rats were sacrificed after 12 weeks’ feeding.
Tissues were obtained for cytokines tests.
Results.
Firstly, high-fat diet feeding led to significant obesity.
Compared to NG, the level of SOD in the liver, spleen, lung, and kidney was much lower in OG (p<0.05), while the pathological scores of pancreas, liver, spleen, lung, and kidney were much higher.
SJP significantly increased SOD level in the liver, spleen, and lung and reduced the pathological scores of pancreas, liver, spleen, lung, and kidney correspondingly (p<0.05).
Conclusions.
SJP ameliorates inflammatory response and mitigates obesity-induced multiple organ injuries.
American Psychological Association (APA)
Li, Juan& Zhang, Yumei& Li, Jun-yi& Zhu, Lv& Kang, Hong-xin& Ren, Hong-yu…[et al.]. 2017. Effect of Sheng-Jiang Powder on Obesity-Induced Multiple Organ Injuries in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1154355
Modern Language Association (MLA)
Li, Juan…[et al.]. Effect of Sheng-Jiang Powder on Obesity-Induced Multiple Organ Injuries in Rats. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1154355
American Medical Association (AMA)
Li, Juan& Zhang, Yumei& Li, Jun-yi& Zhu, Lv& Kang, Hong-xin& Ren, Hong-yu…[et al.]. Effect of Sheng-Jiang Powder on Obesity-Induced Multiple Organ Injuries in Rats. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1154355
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154355