Isolation and Biological Evaluation of Prenylated Flavonoids from Maclura pomifera
Joint Authors
Chaurasiya, Narayan D.
Tekwani, Babu L.
Orazbekov, Yerkebulan
Ibrahim, Mohamed A.
Mombekov, Serjan
Srivedavyasasri, Radhakrishnan
Datkhayev, Ubaidilla
Makhatov, Bauyrzhan
Ross, Samir A.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-14
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Phytochemical analysis of the ethanolic extract of Maclura pomifera fruits yielded four new compounds (I–IV) along with eleven known compounds (V–XV).
The crude extract exhibited significant activity towards cannabinoid receptors (CB1: 103.4% displacement; CB2: 68.8% displacement) and possibly allosteric interaction with δ and μ opioid receptors (−49.7 and −53.8% displacement, resp.).
Compound I was found to be possibly allosteric for κ and μ opioid receptors (−88.4 and −27.2% displacement, resp.) and showed moderate activity (60.5% displacement) towards CB1 receptor.
Compound II exhibited moderate activity towards cannabinoid receptors CB1 and CB2 (47.9 and 42.3% displacement, resp.).
The known compounds (V–VIII) exhibited prominent activity towards cannabinoid receptors: pomiferin (V) (IC50 of 2.110 and 1.318 μM for CB1 and CB2, resp.), auriculasin (VI) (IC50 of 8.923 μM for CB1), warangalone (VII) (IC50 of 1.670 and 4.438 μM for CB1 and CB2, resp.), and osajin (VIII) (IC50 of 3.859 and 7.646 μM for CB1 and CB2, resp.).
The isolated compounds were also tested for inhibition of human monoamine oxidase-A and monoamine oxidase-B enzymes activities, where all the tested compounds showed fewer inhibitory effects on MAO-A compared to MAO-B activities: auriculasin (VI) (IC50 of 1.91 and 45.98 μM for MAO-B and MAO-A, resp.).
American Psychological Association (APA)
Orazbekov, Yerkebulan& Ibrahim, Mohamed A.& Mombekov, Serjan& Srivedavyasasri, Radhakrishnan& Datkhayev, Ubaidilla& Makhatov, Bauyrzhan…[et al.]. 2018. Isolation and Biological Evaluation of Prenylated Flavonoids from Maclura pomifera. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1154393
Modern Language Association (MLA)
Orazbekov, Yerkebulan…[et al.]. Isolation and Biological Evaluation of Prenylated Flavonoids from Maclura pomifera. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1154393
American Medical Association (AMA)
Orazbekov, Yerkebulan& Ibrahim, Mohamed A.& Mombekov, Serjan& Srivedavyasasri, Radhakrishnan& Datkhayev, Ubaidilla& Makhatov, Bauyrzhan…[et al.]. Isolation and Biological Evaluation of Prenylated Flavonoids from Maclura pomifera. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1154393
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154393