The Bioavailability and Pharmacokinetics of Silymarin SMEDDS Formulation Study in Healthy Thai Volunteers
Joint Authors
Sornsuvit, Chuleegone
Hongwiset, Darunee
Yotsawimonwat, Songwut
Toonkum, Manatchaya
Thongsawat, Satawat
Taesotikul, Wandee
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-19
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The present study aimed to determine the pharmacokinetic parameters and bioavailability of silymarin 140 mg SMEDDS formulation.
An open-label, single-dose pharmacokinetic study was conducted.
Twelve healthy volunteers were included in the study.
After the volunteers had fasted overnight for 10 h, a single-dose generic silymarin 140 mg SMEDDS soft capsule was administered.
Then 10 ml blood samples were taken at 0.0, 0.25, 0.50, 0.75, 1.0, 1.33, 1.67, 2.0, 2.5, 3.0, 4.0, 6.0, 8.0, 10.0, and 12.0 h.
The plasma silybin concentrations were analyzed using validated LC-MS/MS.
The pharmacokinetic parameters were analyzed and calculated.
The pharmacokinetic parameters were calculated after silymarin had been administered as a single capsule.
The mean (range) Cmax was 812.43 (259.47–1505.47) ng/ml at 0.80 (0.25–1.67) h (tmax).
The mean (range) AUC0-t and AUC0-inf were 658.80 (268.29–1045.01) ng.h/ml and 676.98 (274.10–1050.96) ng.h/ml, respectively.
The mean ke and t1/2 were 0.5386 h-1 and 1.91 h, respectively.
The silymarin SMEDDS formulation soft capsule showed rapid absorption and high oral bioavailability.
American Psychological Association (APA)
Sornsuvit, Chuleegone& Hongwiset, Darunee& Yotsawimonwat, Songwut& Toonkum, Manatchaya& Thongsawat, Satawat& Taesotikul, Wandee. 2018. The Bioavailability and Pharmacokinetics of Silymarin SMEDDS Formulation Study in Healthy Thai Volunteers. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1154410
Modern Language Association (MLA)
Sornsuvit, Chuleegone…[et al.]. The Bioavailability and Pharmacokinetics of Silymarin SMEDDS Formulation Study in Healthy Thai Volunteers. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1154410
American Medical Association (AMA)
Sornsuvit, Chuleegone& Hongwiset, Darunee& Yotsawimonwat, Songwut& Toonkum, Manatchaya& Thongsawat, Satawat& Taesotikul, Wandee. The Bioavailability and Pharmacokinetics of Silymarin SMEDDS Formulation Study in Healthy Thai Volunteers. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1154410
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154410