Inhibition of Aortic Intimal Hyperplasia and Vascular Smooth Muscle Proliferation and Extracellular Matrix Protein Expressions by Astragalus–Angelica Combination
Joint Authors
Yan, Huifang
Peng, Xiwei
Xu, Hao
Zhu, Jiahuan
Deng, Changqing
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-08-13
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
VSMC proliferation and ECM deposition always resulted in intimal hyperplasia.
Astragalus–Angelica combination has a protective effect on the cardiovascular system.
The inhibition effect of different Astragalus–Angelica combination on the hyperplastic intima after vascular balloon injury in rats was investigated in this study.
Astragalus–Angelica combination can inhibit the intima hyperplasia after balloon injury, in which a 1:1 ratio shows excellent results.
Astragalus–Angelica combination can enhance the expression of smooth muscle α-actin (SMа-actin) and inhibit the expression of proliferating cell nuclear antigen (PCNA), cyclin D1, cyclin E, collagen I (Col-I), fibronectin (FN), and matrix metallopeptidase-9 (MMP-9) in hyperplastic intima, suggesting that Astragalus–Angelica combination can inhibit the intimal hyperplasia of blood vessels in rats.
The mechanism is related to the inhibition of PI3K/Akt signaling pathway activation and thereby inhibits the phenotypic transformation and cell proliferation of VSMCs and thus inhibits the extracellular matrix (ECM) deposition of vascular wall during intimal hyperplasia.
American Psychological Association (APA)
Yan, Huifang& Peng, Xiwei& Xu, Hao& Zhu, Jiahuan& Deng, Changqing. 2018. Inhibition of Aortic Intimal Hyperplasia and Vascular Smooth Muscle Proliferation and Extracellular Matrix Protein Expressions by Astragalus–Angelica Combination. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1154412
Modern Language Association (MLA)
Yan, Huifang…[et al.]. Inhibition of Aortic Intimal Hyperplasia and Vascular Smooth Muscle Proliferation and Extracellular Matrix Protein Expressions by Astragalus–Angelica Combination. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-15.
https://search.emarefa.net/detail/BIM-1154412
American Medical Association (AMA)
Yan, Huifang& Peng, Xiwei& Xu, Hao& Zhu, Jiahuan& Deng, Changqing. Inhibition of Aortic Intimal Hyperplasia and Vascular Smooth Muscle Proliferation and Extracellular Matrix Protein Expressions by Astragalus–Angelica Combination. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1154412
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154412