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Sinomenine Hydrochloride Attenuates Renal Fibrosis by Inhibiting Excessive Autophagy Induced by Adriamycin: An Experimental Study
Joint Authors
Yang, Bin
Zhao, Ming-ming
Zhang, Qiu
Wang, Jin-hu
Zhao, Jin-ning
Zhang, Yu
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-17
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The objective of this study is to investigate if sinomenine hydrochloride (SIN-HCl) could be effective against adriamycin-induced renal fibrosis by regulating autophagy in a rat model.
Forty male Sprague-Dawley (SD) rats were randomly divided into control group, model group, telmisartan group, and SIN-HCl group; rat model was induced by adriamycin; all rats were given intragastric administration for 6 weeks.
Urine was collected from rats in metabolic cages to determine 24 h protein level.
This was done after intragastric administration for the first two weeks and then once for every two weeks.
Renal pathological changes were examined by the staining of HE, Masson, and PASM.
Expressions and distributions of fibronectin (FN), laminin (LN), light chain 3 (LC3), and Beclin-1 were observed by immunohistochemistry.
SIN-HCl ameliorates proteinuria, meanwhile attenuating the renal pathological changes in adriamycin-induced rats and also attenuating renal fibrosis and excessive autophagy by reducing the expression of FN, LN, LC3, and Beclin-1.
SIN-HCl attenuates renal fibrosis by inhibiting excessive autophagy induced by adriamycin and upregulates the basal autophagy.
American Psychological Association (APA)
Zhao, Ming-ming& Yang, Bin& Zhang, Qiu& Wang, Jin-hu& Zhao, Jin-ning& Zhang, Yu. 2017. Sinomenine Hydrochloride Attenuates Renal Fibrosis by Inhibiting Excessive Autophagy Induced by Adriamycin: An Experimental Study. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1154413
Modern Language Association (MLA)
Zhao, Ming-ming…[et al.]. Sinomenine Hydrochloride Attenuates Renal Fibrosis by Inhibiting Excessive Autophagy Induced by Adriamycin: An Experimental Study. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1154413
American Medical Association (AMA)
Zhao, Ming-ming& Yang, Bin& Zhang, Qiu& Wang, Jin-hu& Zhao, Jin-ning& Zhang, Yu. Sinomenine Hydrochloride Attenuates Renal Fibrosis by Inhibiting Excessive Autophagy Induced by Adriamycin: An Experimental Study. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1154413
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154413