Restructuring Reward Mechanisms in Nicotine Addiction: A Pilot fMRI Study of Mindfulness-Oriented Recovery Enhancement for Cigarette Smokers

Joint Authors

Froeliger, Brett
Mathew, A. R.
McConnell, P. A.
Eichberg, C.
Saladin, M. E.
Carpenter, M. J.
Garland, E. L.

Source

Evidence-Based Complementary and Alternative Medicine

Issue

Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2017-03-08

Country of Publication

Egypt

No. of Pages

10

Main Subjects

Medicine

Abstract EN

The primary goal of this pilot feasibility study was to examine the effects of Mindfulness-Oriented Recovery Enhancement (MORE), a behavioral treatment grounded in dual-process models derived from cognitive science, on frontostriatal reward processes among cigarette smokers.

Healthy adult (N=13; mean (SD) age 49 ± 12.2) smokers provided informed consent to participate in a 10-week study testing MORE versus a comparison group (CG).

All participants underwent two fMRI scans: pre-tx and after 8-weeks of MORE.

Emotion regulation (ER), smoking cue reactivity (CR), and resting-state functional connectivity (rsFC) were assessed at each fMRI visit; smoking and mood were assessed throughout.

As compared to the CG, MORE significantly reduced smoking (d=2.06) and increased positive affect (d=2.02).

MORE participants evidenced decreased CR-BOLD response in ventral striatum (VS; d=1.57) and ventral prefrontal cortex (vPFC; d=1.7) and increased positive ER-BOLD in VS (dVS=2.13) and vPFC (dvmPFC=2.66).

Importantly, ER was correlated with smoking reduction (r’s = .68 to .91) and increased positive affect (r’s = .52 to .61).

These findings provide preliminary evidence that MORE may facilitate the restructuring of reward processes and play a role in treating the pathophysiology of nicotine addiction.

American Psychological Association (APA)

Froeliger, Brett& Mathew, A. R.& McConnell, P. A.& Eichberg, C.& Saladin, M. E.& Carpenter, M. J.…[et al.]. 2017. Restructuring Reward Mechanisms in Nicotine Addiction: A Pilot fMRI Study of Mindfulness-Oriented Recovery Enhancement for Cigarette Smokers. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1154427

Modern Language Association (MLA)

Froeliger, Brett…[et al.]. Restructuring Reward Mechanisms in Nicotine Addiction: A Pilot fMRI Study of Mindfulness-Oriented Recovery Enhancement for Cigarette Smokers. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1154427

American Medical Association (AMA)

Froeliger, Brett& Mathew, A. R.& McConnell, P. A.& Eichberg, C.& Saladin, M. E.& Carpenter, M. J.…[et al.]. Restructuring Reward Mechanisms in Nicotine Addiction: A Pilot fMRI Study of Mindfulness-Oriented Recovery Enhancement for Cigarette Smokers. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1154427

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1154427