Cartilage Protection and Analgesic Activity of a Botanical Composition Comprised of Morus alba, Scutellaria baicalensis, and Acacia catechu
Joint Authors
Yimam, Mesfin
Jiao, Ping
Brownell, Lidia
Horm, Teresa
Wright, Laura
Jia, Qi
Hong, Mei
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-20
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Although there have been augmented advances in drug discovery, current OA management is inadequate due to the lack of successful therapies proven to be effective in modifying disease progression.
For some, the risk outweighs the benefit.
As a result, there is a desperate need for safe and efficacious natural alternatives.
Here we evaluated a composition from Morus alba, Scutellaria baicalensis, and Acacia catechu in maintaining joint structural integrity and alleviating OA associated symptoms in monoiodoacetate- (MIA-) induced rat OA disease model.
Study lasted for 6 weeks.
59.6%, 64.6%, 70.7%, 69.9%, and 70.3% reductions in pain sensitivity were observed for rats treated with the composition from week 1 to week 5, respectively.
Statistically significant improvements in articular cartilage matrix integrity (maintained at 57.1% versus MIA + vehicle treated rats) were shown from the modified total Mankin score for animals treated with the composition.
The composition showed a statistically significant reduction in uCTX-II level (54.1% reductions).
The merit of combining these botanicals was also demonstrated in their synergistic analgesic activity.
Therefore, the standardized blend of Morus alba, Scutellaria baicalensis, and Acacia catechu could potentially be considered as an alternative remedy from natural sources for the management of OA and/or its associated symptoms.
American Psychological Association (APA)
Yimam, Mesfin& Horm, Teresa& Wright, Laura& Jiao, Ping& Hong, Mei& Brownell, Lidia…[et al.]. 2017. Cartilage Protection and Analgesic Activity of a Botanical Composition Comprised of Morus alba, Scutellaria baicalensis, and Acacia catechu. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1154430
Modern Language Association (MLA)
Yimam, Mesfin…[et al.]. Cartilage Protection and Analgesic Activity of a Botanical Composition Comprised of Morus alba, Scutellaria baicalensis, and Acacia catechu. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1154430
American Medical Association (AMA)
Yimam, Mesfin& Horm, Teresa& Wright, Laura& Jiao, Ping& Hong, Mei& Brownell, Lidia…[et al.]. Cartilage Protection and Analgesic Activity of a Botanical Composition Comprised of Morus alba, Scutellaria baicalensis, and Acacia catechu. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1154430
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154430