Cardioprotection against Heart Failure by Shenfu Injection via TGF-βSmads Signaling Pathway
Joint Authors
Zhu, Jin-qiang
Zhu, Yan
Chen, Jingrui
Ni, Jingyu
Li, Lingyan
Fan, Guanwei
Shi, Yang
Li, Lan
Li, Min
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-15
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Objective.
To explore the potential cardioprotective mechanism of Shenfu injection (SFI) against heart failure (HF) by attenuating myocardial fibrosis and cardiac remodeling.
Methods and Results.
Four weeks after myocardial infarction (MI), adult male Sprague Dawley rats were randomized for 4-week treatment with Valsartan, SFI, or vehicle.
Echocardiography and hemodynamics were applied to evaluate cardiac functions.
Myocardia of coronary artery ligated (CAD) rats were observed to investigate changes in cardiac structure and function.
Our findings suggest that treatment with SFI could inhibit progression of myocardial fibrosis and attenuate cardiac remodeling.
In addition, SFI decreased expression of Smad2 and Smad3, while increasing the expression of Smad7 through regulation of TGF-β/Smads signaling pathway.
Conclusion.
Treatment with SFI in Sprague Dawley rats improves ventricular structure and function and reduces cardiac fibrosis by ameliorating TGF-β/Smads signaling pathway after ventricular remodeling.
American Psychological Association (APA)
Ni, Jingyu& Shi, Yang& Li, Lan& Chen, Jingrui& Li, Lingyan& Li, Min…[et al.]. 2017. Cardioprotection against Heart Failure by Shenfu Injection via TGF-βSmads Signaling Pathway. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1154436
Modern Language Association (MLA)
Ni, Jingyu…[et al.]. Cardioprotection against Heart Failure by Shenfu Injection via TGF-βSmads Signaling Pathway. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-16.
https://search.emarefa.net/detail/BIM-1154436
American Medical Association (AMA)
Ni, Jingyu& Shi, Yang& Li, Lan& Chen, Jingrui& Li, Lingyan& Li, Min…[et al.]. Cardioprotection against Heart Failure by Shenfu Injection via TGF-βSmads Signaling Pathway. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1154436
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154436