Soybean Milk Inhibits Absorption and Intestinal Transmembrane Transport of Gegen in Rats
Joint Authors
Chen, Fei-long
Tan, Xiao-mei
Ling, Xiao
Tang, Qingfa
Xiang, Yuqiang
Jin, Zhen
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-30
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Puerariae Lobatae Radix, known as Gegen in Chinese, is widely used to treat cardiovascular diseases, diabetes, and many other chronic illnesses.
Flavonoids are the main active components in Gegen and are found in high concentrations in soybeans.
Few studies, however, have focused on the effects of flavonoid-rich food on the absorption of Gegen.
Here, we report an in vivo pharmacokinetic study on rats to explore the effects of soybean milk on the absorption of Gegen and an in vitro Ussing chamber study of puerarin intestinal transmembrane absorption.
Area under the plasma concentration-time curve (AUC0–t) and maximum plasma concentration (Cmax) values of puerarin in rats were significantly decreased after drinking soybean milk, when taking Gegen decoction or a Gegen patent medicine (P < 0.01).
In the Ussing chamber experiment, cumulative transmission (Qtn) after 2 h and apparent permeability coefficient (Papp) were lower in the puerarin-daidzin and puerarin-soybean milk solution groups than in the puerarin group.
Daidzin in soybean milk inhibited the transmembrane transport of puerarin, resulting in decreased bioavailability of puerarin in Gegen.
The results of this study strongly suggest that Gegen should not be taken with flavonoid-rich food, particularly soybean products.
American Psychological Association (APA)
Ling, Xiao& Xiang, Yuqiang& Tang, Qingfa& Jin, Zhen& Chen, Fei-long& Tan, Xiao-mei. 2017. Soybean Milk Inhibits Absorption and Intestinal Transmembrane Transport of Gegen in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1154455
Modern Language Association (MLA)
Ling, Xiao…[et al.]. Soybean Milk Inhibits Absorption and Intestinal Transmembrane Transport of Gegen in Rats. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1154455
American Medical Association (AMA)
Ling, Xiao& Xiang, Yuqiang& Tang, Qingfa& Jin, Zhen& Chen, Fei-long& Tan, Xiao-mei. Soybean Milk Inhibits Absorption and Intestinal Transmembrane Transport of Gegen in Rats. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1154455
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154455