Effect of Abnormal Savda Munziq, a Traditional Uighur Herbal Medicine, on Pulmonary Function and Aquaporins of COPD Rat Model with Abnormal Savda Syndrome
Joint Authors
Wang, Jing
Li, Feng-sen
Zhen, Gao
Jing, Jing
Zheng, Li
Dan, Xu
Halmurati, Upur
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-29
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
To investigate the effect of abnormal savda munziq (ASM) on the pulmonary function and expression of lung-specific aquaporins in the rat model of chronic obstructive pulmonary disease with abnormal savda syndrome (ASSCOPD).
Methods.
Eighty male rats were randomized into ASSCOPD, COPD, and control groups.
ASSCOPD was further categorized into ASM and non-ASM groups.
COPD model was established by combining fumigation with airway instillation of elastase; ASSCOPD model was developed based on COPD by induction with dry cold diet, cold dry environment, and plantar electric stimulation.
ASM was administered twice daily.
The pulmonary function was evaluated based on respiration.
The mRNA and protein levels of AQPs were estimated by real-time PCR and Western blot, respectively.
Results.
MV, TV, the mRNA level of AQP5, and the protein expression of AQP1, AQP4, and AQP5 were increased in ASMCOPD compared to ASSCOPD.
Conclusion.
The pulmonary function was impaired in ASSCOPD group; the expression of AQP1, AQP4, and AQP5 was decreased at protein and mRNA levels in ASSCOPD group.
ASM can improve the pulmonary function in ASSCOPD for MV and TV.
ASM could elevate the protein expression of AQP1, AQP4, and AQP5 and the mRNA level of AQP5 in lung tissue.
American Psychological Association (APA)
Zhen, Gao& Halmurati, Upur& Wang, Jing& Jing, Jing& Zheng, Li& Dan, Xu…[et al.]. 2017. Effect of Abnormal Savda Munziq, a Traditional Uighur Herbal Medicine, on Pulmonary Function and Aquaporins of COPD Rat Model with Abnormal Savda Syndrome. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1154464
Modern Language Association (MLA)
Zhen, Gao…[et al.]. Effect of Abnormal Savda Munziq, a Traditional Uighur Herbal Medicine, on Pulmonary Function and Aquaporins of COPD Rat Model with Abnormal Savda Syndrome. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1154464
American Medical Association (AMA)
Zhen, Gao& Halmurati, Upur& Wang, Jing& Jing, Jing& Zheng, Li& Dan, Xu…[et al.]. Effect of Abnormal Savda Munziq, a Traditional Uighur Herbal Medicine, on Pulmonary Function and Aquaporins of COPD Rat Model with Abnormal Savda Syndrome. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1154464
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154464