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Probiotic Cell-Free Supernatants Exhibited Anti-Inflammatory and Antioxidant Activity on Human Gut Epithelial Cells and Macrophages Stimulated with LPS
Joint Authors
Traina, Giovanna
De Marco, Stefania
Piccioni, Miranda
Pagiotti, Rita
Pietrella, Donatella
Sichetti, Marzia
Muradyan, Diana
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-04
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The incidence of inflammatory bowel disease is increasing all over the world, especially in industrialized countries.
The aim of the present work was to verify the anti-inflammatory activity of metabolites.
In particular, cell-free supernatants of Lactobacillus acidophilus, Lactobacillus casei, Lactococcus lactis, Lactobacillus reuteri, and Saccharomyces boulardii have been investigated.
Metabolites produced by these probiotics were able to downregulate the expression of PGE-2 and IL-8 in human colon epithelial HT-29 cells.
Moreover, probiotic supernatants can differently modulate IL-1β, IL-6, TNF-α, and IL-10 production by human macrophages, suggesting a peculiar anti-inflammatory activity.
Furthermore, supernatants showed a significant dose-dependent radical scavenging activity.
This study suggests one of the mechanisms by which probiotics exert their anti-inflammatory activity affecting directly the intestinal epithelial cells and the underlying macrophages.
This study provides a further evidence to support the possible use of probiotic metabolites in preventing and downregulating intestinal inflammation as adjuvant in anti-inflammatory therapy.
American Psychological Association (APA)
De Marco, Stefania& Sichetti, Marzia& Muradyan, Diana& Piccioni, Miranda& Traina, Giovanna& Pagiotti, Rita…[et al.]. 2018. Probiotic Cell-Free Supernatants Exhibited Anti-Inflammatory and Antioxidant Activity on Human Gut Epithelial Cells and Macrophages Stimulated with LPS. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1154467
Modern Language Association (MLA)
De Marco, Stefania…[et al.]. Probiotic Cell-Free Supernatants Exhibited Anti-Inflammatory and Antioxidant Activity on Human Gut Epithelial Cells and Macrophages Stimulated with LPS. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1154467
American Medical Association (AMA)
De Marco, Stefania& Sichetti, Marzia& Muradyan, Diana& Piccioni, Miranda& Traina, Giovanna& Pagiotti, Rita…[et al.]. Probiotic Cell-Free Supernatants Exhibited Anti-Inflammatory and Antioxidant Activity on Human Gut Epithelial Cells and Macrophages Stimulated with LPS. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1154467
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154467