Bushenkangshuai Tablet Reduces Atherosclerotic Lesion by Improving Blood Lipids Metabolism and Inhibiting Inflammatory Response via TLR4 and NF-κB Signaling Pathway
Joint Authors
Zhang, Junping
Pang, Shu-chao
Wang, Yuan-yuan
Jia, Hui-yun
Bi, Li-yuan
Peng, Li
Chen, Mei-ling
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-24
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Bushenkangshuai tablet (BSKS) is a Chinese herbal compound which has been used for the treatment of cardiovascular and cerebrovascular diseases in China for decades.
This study intends to explore the molecular mechanism of BSKS against atherosclerosis in ApoE−/− mice.
ApoE−/− mice were fed with western-type diet for 6 weeks and then were given BSKS for 6 weeks.
The results showed that BSKS attenuated the size of the atherosclerotic lesion, reduced visceral adipose content, and decreased blood lipids.
We also found that BSKS promoted the expression of adiponectin and its receptors, inhibited the expression of Toll-like receptor 4 and nuclear factor-kappa B, decreased the levels of interleukin-1 beta, monocyte chemotactic protein-1, and vascular cell adhesion molecule-1, and increased the levels of interleukin-10 and adiponectin.
Our data provided evidence that BSKS exerted an antiatherosclerotic effect by lowering blood lipids and inhibiting inflammatory response via TLR4 and NF-κB signaling pathway.
American Psychological Association (APA)
Pang, Shu-chao& Peng, Li& Zhang, Junping& Wang, Yuan-yuan& Jia, Hui-yun& Bi, Li-yuan…[et al.]. 2018. Bushenkangshuai Tablet Reduces Atherosclerotic Lesion by Improving Blood Lipids Metabolism and Inhibiting Inflammatory Response via TLR4 and NF-κB Signaling Pathway. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1154470
Modern Language Association (MLA)
Pang, Shu-chao…[et al.]. Bushenkangshuai Tablet Reduces Atherosclerotic Lesion by Improving Blood Lipids Metabolism and Inhibiting Inflammatory Response via TLR4 and NF-κB Signaling Pathway. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1154470
American Medical Association (AMA)
Pang, Shu-chao& Peng, Li& Zhang, Junping& Wang, Yuan-yuan& Jia, Hui-yun& Bi, Li-yuan…[et al.]. Bushenkangshuai Tablet Reduces Atherosclerotic Lesion by Improving Blood Lipids Metabolism and Inhibiting Inflammatory Response via TLR4 and NF-κB Signaling Pathway. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1154470
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154470