Targeting Tumor Microenvironment: Effects of Chinese Herbal Formulae on Macrophage-Mediated Lung Cancer in Mice
Joint Authors
Dong, Jing-cheng
Wei, Ying
Liu, Jiaqi
Xu, Fei
Liu, Baojun
Qiu, Jian
Yan, Chen
Li, Mihui
Cui, Wenqiang
Zhao, Zhengxiao
Gong, Weiyi
Li, Qiuping
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-28
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Our previous studies have shown that Qing-Re-Huo-Xue (QRHX) formulae had significant anti-inflammatory effects in chronic airway diseases such as asthma and chronic obstructive lung disease.
Here, we examined the effects of QRHX on lung cancer cell invasion and the potential associated mechanism(s), mainly polarization of macrophages in the tumor microenvironment.
In vivo, QRHX both inhibited tumor growth and decreased the number of tumor-associated macrophages (TAMs) in mice with lung cancer.
Further study indicated that QRHX inhibited cancer-related inflammation in tumor by decreasing infiltration of TAMs and IL-6 and TNF-α production and meanwhile decreased arginase 1 (Arg-1) expression and increased inducible NO synthase (iNOS) expression.
QRHX could markedly inhibit CD31 and VEGF protein expression.
Additionally, CXCL12/CXCR4 expression and JAK2/STAT3 phosphorylation were reduced in QRHX treatment group.
Thus, we draw that QRHX played a more important role in inhibiting tumor growth by regulating TAMs in mice, which was found to be associated with the inhibition of inflammation and the CXCL12/CXCR4/JAK2/STAT3 signaling pathway.
American Psychological Association (APA)
Xu, Fei& Cui, Wenqiang& Zhao, Zhengxiao& Gong, Weiyi& Wei, Ying& Liu, Jiaqi…[et al.]. 2017. Targeting Tumor Microenvironment: Effects of Chinese Herbal Formulae on Macrophage-Mediated Lung Cancer in Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1154471
Modern Language Association (MLA)
Xu, Fei…[et al.]. Targeting Tumor Microenvironment: Effects of Chinese Herbal Formulae on Macrophage-Mediated Lung Cancer in Mice. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1154471
American Medical Association (AMA)
Xu, Fei& Cui, Wenqiang& Zhao, Zhengxiao& Gong, Weiyi& Wei, Ying& Liu, Jiaqi…[et al.]. Targeting Tumor Microenvironment: Effects of Chinese Herbal Formulae on Macrophage-Mediated Lung Cancer in Mice. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1154471
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154471