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Effects of Chicory on Serum Uric Acid, Renal Function, and GLUT9 Expression in Hyperuricaemic Rats with Renal Injury and In Vitro Verification with Cells
Joint Authors
Jin, Yong-Nan
Lin, Zhi-Jian
Zhang, Bing
Bai, Yun-Fei
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-12-02
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Hyperuricaemia (HUA) is an independent risk factor for chronic kidney disease.
Urate crystals are deposited in the kidney and can cause renal tubular interstitial fibrosis, leading to renal dysfunction.
Chicory extract (hereafter referred to as chicory) clearly reduced serum uric acid levels in rats with HUA induced by 10% fructose.
This is the first study to observe the effect of chicory on serum uric acid levels and renal function in rats with HUA and renal injury.
In vivo studies using hyperuricaemic rats with renal injury induced by yeast and adenine demonstrated that chicory decreased serum uric acid level, and its effect of delaying the progression of kidney injury was better than that of benzbromarone.
In vitro cell experiments showed that this effect is related to the inhibition of GLUT9 protein expression in renal tubules and that lowering blood uric acid concentrations is one of the factors that alleviates renal damage.
The results of this study indicate that chicory can be used as an alternative for alleviating renal dysfunction in hyperuricaemia.
American Psychological Association (APA)
Jin, Yong-Nan& Lin, Zhi-Jian& Zhang, Bing& Bai, Yun-Fei. 2018. Effects of Chicory on Serum Uric Acid, Renal Function, and GLUT9 Expression in Hyperuricaemic Rats with Renal Injury and In Vitro Verification with Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1154474
Modern Language Association (MLA)
Jin, Yong-Nan…[et al.]. Effects of Chicory on Serum Uric Acid, Renal Function, and GLUT9 Expression in Hyperuricaemic Rats with Renal Injury and In Vitro Verification with Cells. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1154474
American Medical Association (AMA)
Jin, Yong-Nan& Lin, Zhi-Jian& Zhang, Bing& Bai, Yun-Fei. Effects of Chicory on Serum Uric Acid, Renal Function, and GLUT9 Expression in Hyperuricaemic Rats with Renal Injury and In Vitro Verification with Cells. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1154474
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154474