Major Phytochemical as γ-Sitosterol Disclosing and Toxicity Testing in Lagerstroemia Species
Joint Authors
Sirikhansaeng, Prapaparn
Tanee, Tawatchai
Sudmoon, Runglawan
Chaveerach, Arunrat
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-16
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Medicinal plants in genus Lagerstroemia were investigated for phytochemical contents by GC-MS and HPLC with ethanol and hexane extracts and their toxicity MTT and comet assay on human peripheral blood mononuclear cells (PBMCs).
γ-Sitosterol is the major component found in all species at 14.70–34.44%.
All of the extracts, except for L.
speciosa ethanol extract, showed high percentages of cell viability.
The IC50 value, 0.24 mg/mL, of ethanol L.
speciosa extract predicted an LD50 of 811.78 mg/kg, which belongs to WHO Class III of toxic chemicals.
However, in-depth toxicity evaluation by the comet assay showed that the four tested species induced significant (p<0.05) DNA damage in PBMCs.
γ-Sitosterol was previously reported to possess antihyperglycemic activity by increasing insulin secretion in response to glucose.
Nonetheless, consumers should consider its toxicity, and the amount of consumption should be of concern.
American Psychological Association (APA)
Sirikhansaeng, Prapaparn& Tanee, Tawatchai& Sudmoon, Runglawan& Chaveerach, Arunrat. 2017. Major Phytochemical as γ-Sitosterol Disclosing and Toxicity Testing in Lagerstroemia Species. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1154476
Modern Language Association (MLA)
Sirikhansaeng, Prapaparn…[et al.]. Major Phytochemical as γ-Sitosterol Disclosing and Toxicity Testing in Lagerstroemia Species. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1154476
American Medical Association (AMA)
Sirikhansaeng, Prapaparn& Tanee, Tawatchai& Sudmoon, Runglawan& Chaveerach, Arunrat. Major Phytochemical as γ-Sitosterol Disclosing and Toxicity Testing in Lagerstroemia Species. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1154476
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154476