An Ethanolic Extract of Allium hookeri Root Alleviates Reflux Esophagitis and Modulates NF-κB Signaling

Joint Authors

Lee, Jeong-Ho
Moon, Kwang Hyun
Nan, Li
Nam, Hyeon Hwa
Choo, Byung Kil
Park, Jin Cheon
Kim, Dae Geun

Source

Evidence-Based Complementary and Alternative Medicine

Issue

Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2018-10-08

Country of Publication

Egypt

No. of Pages

8

Main Subjects

Medicine

Abstract EN

Reflux esophagitis (RE) is a kind of gastroesophageal reflux disease, of which an esophageal inflammatory lesion is caused by the contents of the stomach and duodenum flowing back into the esophagus.

Allium hookeri is a plant possessing both nutritional and medicinal properties.

In our study, we investigated the inhibition effect of inflammation of A.

hookeri root extract (AHE) on inflammatory RAW264.7 macrophage cells induced by lipopolysaccharide and rat models of RE.

The results showed that AHE significantly reduced the production of nitric oxide (NO) and the protein expression levels of various mediators related to inflammation including inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and inflammatory cytokines such as interleukin-1 beta (IL-1β) and tumor necrosis factor-alpha (TNF-α).

Furthermore, AHE also inhibited the nuclear translocation of nuclear factor kappa B (NF-κB) by inhibiting the phosphorylation IκBα.

In addition, AHE administration significantly ameliorated esophageal mucosal damage upon histological evaluation of RE in rats.

AHE was also found to downregulate the expression levels of proteins such as COX-2, TNF-α, and IL-1β in the rat esophagus.

AHE markedly attenuated activation of NF-κB and phosphorylation of IκBα at the same time.

These results indicated that AHE suppressed LPS-induced inflammatory responses in RAW264.7 cells and may help reduce the development of esophagitis through the modulation of inflammation by regulating NF-κB activation.

American Psychological Association (APA)

Nan, Li& Nam, Hyeon Hwa& Choo, Byung Kil& Park, Jin Cheon& Kim, Dae Geun& Lee, Jeong-Ho…[et al.]. 2018. An Ethanolic Extract of Allium hookeri Root Alleviates Reflux Esophagitis and Modulates NF-κB Signaling. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1154482

Modern Language Association (MLA)

Nan, Li…[et al.]. An Ethanolic Extract of Allium hookeri Root Alleviates Reflux Esophagitis and Modulates NF-κB Signaling. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1154482

American Medical Association (AMA)

Nan, Li& Nam, Hyeon Hwa& Choo, Byung Kil& Park, Jin Cheon& Kim, Dae Geun& Lee, Jeong-Ho…[et al.]. An Ethanolic Extract of Allium hookeri Root Alleviates Reflux Esophagitis and Modulates NF-κB Signaling. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1154482

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1154482