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Experimental Study on the Expression of IL-1β and bFGF in Wound Healing Process of Rabbit Cutaneous Infective Wound in Liu-He-Dan
Joint Authors
Lv, Changyao
Wu, Jing
He, Hongbo
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-10
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objective.
This study applied Liu-He-Dan (LHD) to treat the infective wounds of rabbits to explore the mechanism of LHD in promoting wound healing.
Method.
Five circular infective incisions were generated on the back of each rabbit.
Wound dressings were performed every day since postoperative day 1.
Ten rabbits were euthanized on days 3, 7, 14, and 21.
Each specimen was divided into two parts, one was used for detecting interleukin-1 beta (IL-1β), and the other one was used for detecting basic fibroblast growth factor (bFGF).
Result.
The content of IL-1β in the model group was higher than those in the other groups (P<0.05).
The content of IL-1β in the treatment group was lower than the other groups on days 14 and 21.
The expression of bFGF in treatment group is significant on days 3, 7, and 14, compared with traditional Chinese medicine group and model group.
The expression of bFGF has no significant difference with Western group.
Conclusion.
The research approved that LHD could specifically suppress the expression of IL-1β and upregulate the expression of bFGF in the wound, decreasing the release of inflammatory factor of the infective wounds and promoting the healing of the infective wounds.
American Psychological Association (APA)
Lv, Changyao& Wu, Jing& He, Hongbo. 2017. Experimental Study on the Expression of IL-1β and bFGF in Wound Healing Process of Rabbit Cutaneous Infective Wound in Liu-He-Dan. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1154483
Modern Language Association (MLA)
Lv, Changyao…[et al.]. Experimental Study on the Expression of IL-1β and bFGF in Wound Healing Process of Rabbit Cutaneous Infective Wound in Liu-He-Dan. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1154483
American Medical Association (AMA)
Lv, Changyao& Wu, Jing& He, Hongbo. Experimental Study on the Expression of IL-1β and bFGF in Wound Healing Process of Rabbit Cutaneous Infective Wound in Liu-He-Dan. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1154483
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154483