Hesperidin Protects against Acute Alcoholic Injury through Improving Lipid Metabolism and Cell Damage in Zebrafish Larvae
Joint Authors
Lv, Zhi-Ping
Zhou, Zhenting
Zhong, Weichao
Lin, Haiyan
Huang, Peng
Ma, Ning
Zhang, Yuqing
Zhou, Chuying
Lai, Yuling
Huang, Shaohui
Huang, Shiying
Gao, Lei
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-17
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Alcoholic liver disease (ALD) is a series of abnormalities of liver function, including alcoholic steatosis, steatohepatitis, and cirrhosis.
Hesperidin, the major constituent of flavanone in grapefruit, is proved to play a role in antioxidation, anti-inflammation, and reducing multiple organs damage in various animal experiments.
However, the underlying mechanism of resistance to alcoholic liver injury is still unclear.
Thus, we aimed to investigate the protective effects of hesperidin against ALD and its molecular mechanism in this study.
We established an ALD zebrafish larvae model induced by 350 mM ethanol for 32 hours, using wild-type and transgenic line with liver-specific eGFP expression Tg (lfabp10α:eGFP) zebrafish larvae (4 dpf).
The results revealed that hesperidin dramatically reduced the hepatic morphological damage and the expressions of alcohol and lipid metabolism related genes, including cyp2y3, cyp3a65, hmgcra, hmgcrb, fasn, and fads2 compared with ALD model.
Moreover, the findings demonstrated that hesperidin alleviated hepatic damage as well, which is reflected by the expressions of endoplasmic reticulum stress and DNA damage related genes (chop, gadd45αa, and edem1).
In conclusion, this study revealed that hesperidin can inhibit alcoholic damage to liver of zebrafish larvae by reducing endoplasmic reticulum stress and DNA damage, regulating alcohol and lipid metabolism.
American Psychological Association (APA)
Zhou, Zhenting& Zhong, Weichao& Lin, Haiyan& Huang, Peng& Ma, Ning& Zhang, Yuqing…[et al.]. 2017. Hesperidin Protects against Acute Alcoholic Injury through Improving Lipid Metabolism and Cell Damage in Zebrafish Larvae. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1154494
Modern Language Association (MLA)
Zhou, Zhenting…[et al.]. Hesperidin Protects against Acute Alcoholic Injury through Improving Lipid Metabolism and Cell Damage in Zebrafish Larvae. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1154494
American Medical Association (AMA)
Zhou, Zhenting& Zhong, Weichao& Lin, Haiyan& Huang, Peng& Ma, Ning& Zhang, Yuqing…[et al.]. Hesperidin Protects against Acute Alcoholic Injury through Improving Lipid Metabolism and Cell Damage in Zebrafish Larvae. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1154494
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154494