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Tiaolipiwei Acupuncture Reduces Albuminuria by Alleviating Podocyte Lesions in a Rat Model of Diabetic Nephropathy
Joint Authors
Zhang, Zhilong
Li, Xinju
Liu, Liang
Sun, Jiya
Wang, Xu
Zhao, Zhiheng
Yang, Yuanqing
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-23
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
Diabetic nephropathy is a common and serious complication of diabetes and a major cause of end-stage renal disease.
Tiaolipiwei acupuncture is a safe treatment approach that may be effective for lowering albuminuria in diabetic nephropathy.
Yet, the exact mechanisms of this therapeutic effect are unclear.
Methods.
A rodent model of type 2 diabetic nephropathy (T2DN) was induced by a high-fat diet combined with low-dose streptozotocin.
T2DN rats were treated with Tiaolipiwei acupuncture (ACU) for 4, 8, or 12 weeks.
At the end of treatment, urinary and blood samples were collected for analysis.
Transmission electron microscopy was used to observe morphological changes, and protein expression levels of nephrin, CD2AP, podocalyxin, and desmin were quantified in renal tissue.
Results.
Compared to the T2DN groups, the T2DN + ACU groups showed significant improvements in 24-hour urinary protein, serum urea, cholesterol, and triglycerides at all time points.
ACU treatment also improved the density of slit diaphragms.
Simultaneously, ACU promoted the renal expression of nephrin, CD2AP, and podocalyxin and decreased the expression of desmin.
Conclusion.
Our study suggests that Tiaolipiwei acupuncture ameliorates podocyte lesions to reduce albuminuria and prevent the progression of T2DN in a rat model.
American Psychological Association (APA)
Zhang, Zhilong& Li, Xinju& Liu, Liang& Sun, Jiya& Wang, Xu& Zhao, Zhiheng…[et al.]. 2018. Tiaolipiwei Acupuncture Reduces Albuminuria by Alleviating Podocyte Lesions in a Rat Model of Diabetic Nephropathy. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1154499
Modern Language Association (MLA)
Zhang, Zhilong…[et al.]. Tiaolipiwei Acupuncture Reduces Albuminuria by Alleviating Podocyte Lesions in a Rat Model of Diabetic Nephropathy. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1154499
American Medical Association (AMA)
Zhang, Zhilong& Li, Xinju& Liu, Liang& Sun, Jiya& Wang, Xu& Zhao, Zhiheng…[et al.]. Tiaolipiwei Acupuncture Reduces Albuminuria by Alleviating Podocyte Lesions in a Rat Model of Diabetic Nephropathy. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1154499
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154499