The Effects of Chunghyul-Dan, an Agent of Korean Medicine, on a Mouse Model of Traumatic Brain Injury
Joint Authors
Park, Jung-Mi
Bu, Youngmin
Ko, Chang-Nam
Lee, Beom-Joon
Choi, Won-Woo
Park, Seong-Uk
Lee, Kyungjin
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-08
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Chunghyul-Dan (CHD) is the first choice agent for the prevention and treatment of stroke at the Kyung Hee Medical Hospital.
To date, CHD has been reported to have beneficial effects on brain disease in animals and humans, along with antioxidative and anti-inflammatory effects.
The aim of this study was to evaluate the pharmacological effects of CHD on a traumatic brain injury (TBI) mouse model to explore the possibility of CHD use in patients with TBI.
The TBI mouse model was induced using the controlled cortical impact method.
CHD was orally administered twice a day for 5 d after TBI induction; mice were assessed for brain damage, brain edema, blood-brain barrier (BBB) damage, motor deficits, and cognitive impairment.
Treatment with CHD reduced brain damage seen on histological examination and improved motor and cognitive functions.
However, CHD did not reduce brain edema and BBB damage.
In conclusion, CHD could be a candidate agent in the treatment of patients with TBI.
Further studies are needed to assess the exact mechanisms of the effects during the acute-subacute phase and pharmacological activity during the chronic-convalescent phase of TBI.
American Psychological Association (APA)
Choi, Won-Woo& Lee, Kyungjin& Lee, Beom-Joon& Park, Seong-Uk& Park, Jung-Mi& Ko, Chang-Nam…[et al.]. 2017. The Effects of Chunghyul-Dan, an Agent of Korean Medicine, on a Mouse Model of Traumatic Brain Injury. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1154512
Modern Language Association (MLA)
Choi, Won-Woo…[et al.]. The Effects of Chunghyul-Dan, an Agent of Korean Medicine, on a Mouse Model of Traumatic Brain Injury. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1154512
American Medical Association (AMA)
Choi, Won-Woo& Lee, Kyungjin& Lee, Beom-Joon& Park, Seong-Uk& Park, Jung-Mi& Ko, Chang-Nam…[et al.]. The Effects of Chunghyul-Dan, an Agent of Korean Medicine, on a Mouse Model of Traumatic Brain Injury. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1154512
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154512