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Evaluation of the Wound Healing Activity of the Crude Extract of Leaves of Acanthus polystachyus Delile (Acanthaceae)
Joint Authors
Asrade Atnafe, Seyfe
Demilew, Wubante
Adinew, Getnet Mequanint
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-11
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Medicinal plants play indispensable roles to treat various ailments.
Acanthus polystachyus is one of the medicinal plants used traditionally for treatment of wounds.
However, there were no scientific reports documented so far on the wound healing activities of this plant.
Thus, the present study provides a scientific evaluation for the wound healing potential of the crude extract of A.
polystachyus leaves.
Methods.
The crude extraction was carried out using 80% methanol.
The crude extract was prepared in 5% (w/w) and 10% (w/w) ointment and evaluated for wound healing activity using excision, infected, and incision wound models in Swiss albino mice.
Results.
Both 5% and 10% (w/w) ointments significantly reduced period of epithelialization and increased wound contraction rate and tensile strength compared to the negative control group (P < 0.05).
The wound healing activity of 10% (w/w) ointment treated group was greater than 5% (w/w) and nitrofurazone ointment treated groups in S.
aureus infected wound model.
Conclusion.
These results demonstrate that the crude extract of A.
polystachyus leaves possesses wound healing activities.
This justifies the traditional claimed use of the plant for treating uninfected and infected wounds caused by S.
aureus.
American Psychological Association (APA)
Demilew, Wubante& Adinew, Getnet Mequanint& Asrade Atnafe, Seyfe. 2018. Evaluation of the Wound Healing Activity of the Crude Extract of Leaves of Acanthus polystachyus Delile (Acanthaceae). Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1154521
Modern Language Association (MLA)
Demilew, Wubante…[et al.]. Evaluation of the Wound Healing Activity of the Crude Extract of Leaves of Acanthus polystachyus Delile (Acanthaceae). Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1154521
American Medical Association (AMA)
Demilew, Wubante& Adinew, Getnet Mequanint& Asrade Atnafe, Seyfe. Evaluation of the Wound Healing Activity of the Crude Extract of Leaves of Acanthus polystachyus Delile (Acanthaceae). Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1154521
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154521