Cardioprotective Effects of HuoxueAnshen Recipe against Myocardial Injuries Induced by Sleep Deprivation in Rats
Joint Authors
Wang, Jie
Guo, Li-li
Chen, Heng-Wen
Wei, Ben-Jun
Yuan, Rong
Li, Jun-ping
Chen, Zhong
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-04-05
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background.
Traditional Chinese Medicine is extensively used in China and HuoxueAnshen Recipe (HAR) was formulated according to its method in treating CHD accompanied with insomnia in clinic.
However, there are few studies related to the effect of HAR on myocardial injury and sleep disorders.
Purpose.
To investigate the effects of HAR on sleep deprivation- (SD-) induced myocardial I/R injury.
Methods.
Male Wistar rats receiving a daily gavage of HAR or vehicle were exposed to SD intervention while control rats had normal sleep.
Then all rats were exposed to myocardial I/R.
Hormone, vascular endothelial, and inflammatory related factors were detected before and after I/R, while cardiac injury, cardiac function, myocardial infarct size, and apoptosis were detected after I/R.
Results.
Levels of neuropeptide Y, vascular endothelial and inflammatory related factors were significantly increased while melatonin was decreased in vehicle-treated SD rats but not in HAR-treated SD rats after SD.
In addition, cardiac injury, cardiac dysfunction, myocardial infarct size, and myocardial apoptosis were deteriorated in vehicle-treated SD rats but were ameliorated in HAR-treated SD rats after I/R.
Conclusion.
HAR not only improved SD-induced hormone disorders, inflammation, and endothelial dysfunction, but also alleviated I/R injury, which supports protective usage in CHD and psychocardiology.
American Psychological Association (APA)
Yuan, Rong& Guo, Li-li& Chen, Heng-Wen& Li, Jun-ping& Chen, Zhong& Wei, Ben-Jun…[et al.]. 2017. Cardioprotective Effects of HuoxueAnshen Recipe against Myocardial Injuries Induced by Sleep Deprivation in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1154522
Modern Language Association (MLA)
Yuan, Rong…[et al.]. Cardioprotective Effects of HuoxueAnshen Recipe against Myocardial Injuries Induced by Sleep Deprivation in Rats. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1154522
American Medical Association (AMA)
Yuan, Rong& Guo, Li-li& Chen, Heng-Wen& Li, Jun-ping& Chen, Zhong& Wei, Ben-Jun…[et al.]. Cardioprotective Effects of HuoxueAnshen Recipe against Myocardial Injuries Induced by Sleep Deprivation in Rats. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1154522
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154522